《自然》[Nature]13年7月11日出版pdf全文

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Phages naturally coexist in abundance with their bacterial hosts in the mammalian gut. Antibiotic treatment can negatively affect the gut environment and cause immune and metabolic deficiencies. Previously the disruption of intestinal homeostasis has been studied mainly at the level of bacterial species, but here James Collins and colleagues use comparative metagenomics to profile gut phage populations following antibiotic treatment in mice. They find that exposure to ciprofloxacin or ampicillin enriches phage-encoded genes related to antibiotic resistance. Furthermore, phages from antibiotic-treated mice are able to increase resistance in an aerobically cultured naive microbiota. These results suggest that antibiotic treatment increases the frequency of phage integration and stimulates broad host range, which promotes a functional reservoir that is both genetically diverse and highly accessible to gut bacteria. Cover illustration: Jenn Hinkle
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