卵巢癌的干细胞起源--nature最新论文（附原文）

gandanxiaoyang

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nature最新论文提示，卵巢门区（hilum region）的过渡区域存在干细胞（表达ALDH1, LGR5, LEF1, CD133和CK6B），& ?" y- ]) w' k! h: X) t7 E
并且该微环境中的干细胞更易发生恶性肿瘤。该论文对卵巢癌的起源提供了重要线索。
- b# |9 D" r" V' o5 G论文摘要如下：1 s0 o9 \3 O: }, r6 z+ G
Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche2 `; o" w" p  x. w' I

2 C4 E- o; ~/ L; C) J1 }% zEpithelial ovarian cancer (EOC) is the fifth leading cause of cancer deaths among women in the United States, but its pathogenesis is poorly understood1, 2, 3. Some epithelial cancers are known to occur in transitional zones between two types of epithelium, whereas others have been shown to originate in epithelial tissue stem cells4, 5, 6. The stem cell niche of the ovarian surface epithelium (OSE), which is ruptured and regenerates during ovulation, has not yet been defined unequivocally. Here we identify the hilum region of the mouse ovary, the transitional (or junction) area between the OSE, mesothelium and tubal (oviductal) epithelium, as a previously unrecognized stem cell niche of the OSE. We find that cells of the hilum OSE are cycling slowly and express stem and/or progenitor cell markers ALDH1, LGR5, LEF1, CD133 and CK6B. These cells display long-term stem cell properties ex vivo and in vivo, as shown by our serial sphere generation and long-term lineage-tracing assays. Importantly, the hilum cells show increased transformation potential after inactivation of tumour suppressor genes Trp53 and Rb1, whose pathways are altered frequently in the most aggressive and common type of human EOC, high-grade serous adenocarcinoma7, 8. Our study supports experimentally the idea that susceptibility of transitional zones to malignant transformation may be explained by the presence of stem cell niches in those areas. Identification of a stem cell niche for the OSE may have important implications for understanding EOC pathogenesis.5 U: ~: O. M+ ~: U# P# C

# g/ C0 L- C( A8 A7 g: j% N2楼原文 感谢damaoshu 提供

damaoshu

Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche

菠萝妮子春

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