肿瘤干细胞此次真的被找到了吗?
[i=s] 本帖最后由 细胞海洋 于 2012-8-2 20:58 编辑 [/i]最新一期的《Nature》杂志发表了一篇题目叫Defining the mode of tumour growth by clonal analysis的paper，声称三个独立的研究小组在小鼠体内做到了：
跟踪细胞形成肿瘤的过程，他们发现一小部分细胞驱动肿瘤的生长，而想要治愈癌症可能需要将这些细胞清除，他们称这些细胞为肿瘤干细胞。
而今天的生物谷网站根据此内容发表了一篇位居网站头版头条名叫《Nature:终于逮到你了！肿瘤干细胞》的新闻，我觉得这似乎有点武断了，原因有三：1、这些能驱动肿瘤生长的细胞就是肿瘤干细胞吗？我觉得应该叫它们肿瘤启始细胞 为妥；2、杀死这些细胞就能彻底抑制住肿瘤的生长吗？回答肯定是不可能，这一点您们也太小看肿瘤的演化能力了；3、Nature杂志一直有哗众取宠，发些博眼球文章的前科，从体细胞克隆到CSC到iPS，相关的paper都是差不离他及时展现给我们的，这次估计又是一次“故伎重演"。
个人观点，仅作参阅！ [b]Defining the mode of tumour growth by clonal analysis[/b]
Gregory Driessens,Benjamin Beck,Amélie Caauwe,Benjamin D. Simons& Cédric Blanpain
Recent studies using the isolation of a subpopulation of tumour cells followed by their transplantation into immunodeficient mice provide evidence that certain tumours1, 2, including squamous skin tumours3, 4, 5, contain cells with high clonogenic potential that have been referred to as cancer stem cells (CSCs). Until now, CSC properties have only been investigated by transplantation assays, and their existence in unperturbed tumour growth is unproven. Here we make use of clonal analysis of squamous skin tumours using genetic lineage tracing to unravel the mode of tumour growth in vivo in its native environment. To this end, we used a genetic labelling strategy that allows individual tumour cells to be marked and traced over time at different stages of tumour progression. Surprisingly, we found that the majority of labelled tumour cells in benign papilloma have only limited proliferative potential, whereas a fraction has the capacity to persist long term, giving rise to progeny that occupy a significant part of the tumour. As well as confirming the presence of two distinct proliferative cell compartments within the papilloma, mirroring the composition, hierarchy and fate behaviour of normal tissue, quantitative analysis of clonal fate data indicates that the more persistent population has stem-cell-like characteristics and cycles twice per day, whereas the second represents a slower cycling transient population that gives rise to terminally differentiated tumour cells. Such behaviour is shown to be consistent with double-labelling experiments and detailed clonal fate characteristics. By contrast, measurements of clone size and proliferative potential in invasive squamous cell carcinoma show a different pattern of behaviour, consistent with geometric expansion of a single CSC population with limited potential for terminal differentiation. This study presents the first experimental evidence for the existence of CSCs during unperturbed solid tumour growth.
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