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On the cover: The image shows a girl who is thrilled at discovering the 3D organization of the genome. In this issue, Sexton et al. (pp. 458–472) present a high-resolution chromosomal contact map of the Drosophila genome derived from a modified genome-wide chromosome conformation capture approach. In the image, the 3D glasses metaphorically represent Hi-C and its quantitative modeling as tools that allow the girl to “see” 3D chromosome structures. Sexton et al. deduce the 3D genome organization by bioinformatic analysis of chromatin contact maps, comparisons to previously published epigenetic profiles, and iterative cycles of mathematical modeling. Artwork by Cyril Sarrauste de Menthière.
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发表于 2012-2-4 13:59
