谈谈tet和5-hmC

hongjie88

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我看最近有好多关于这个的文章啊，貌似是很火! W; p% w- v  D) a
列几个跟大家分享一下
, ~; Q* F1 V; A# h( @Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development.Cell Stem Cell. 2011 Aug 5; 9(2): 166-752 d* y* w, _: b7 s/ t
Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development.Cell Res. 2011 Jul 126 e+ K4 k: _3 J' V* f
Tissue specific distribution and dynamic changes of 5-hydroxymethylcytosine in mammalian genome.J Biol Chem. 2011 May 24
+ F* z' [6 u2 N# T% dGenome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells.Nature. 2011 May 8; 6 m; Z+ o8 [. @
Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells.Mol Cell. 2011 Apr 20;
& }3 D* K& Z4 [8 jDynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation.Nature. 2011 Apr 3;
; x' E% m5 N; S* ?' }Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.Genes Dev. 2011 Apr 1; 25(7): 679-844 e/ G+ h! B" G' H0 s
Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells.Nature. 2011 Mar 30;
6 L* P/ N: [; m- H7 V7 ITet1 and tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.Cell Stem Cell. 2011 Feb 4; 8(2): 200-130 x6 f  w% a- S4 ]. [
这才半年就有这么多文章。。。
1 q/ n( k) F0 _9 p大家感兴趣的交流一下吧
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hongjie88

回复 hongjie88 的帖子$ `# z+ Q2 r4 v% i. q) o" l% s
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我这有全文的只有几篇，大家继续补充啊~~

kephort

这是一个很好的话题啊，动物细胞DNA的去甲基化问题不甚别了，貌似现在开始逐渐浮出水面了。9 u- P$ m3 P$ x/ n# q/ S

( B; |4 e& A3 T6 m) }" X! `2 LTet到底与DNA去甲基化之间有什么关系？在DNA去甲基化过程中如何起到调控作用？目前文献中采用了哪些方法能说明5-hmc是/否为去甲基化的中间状态？欢迎看了这方面的达人列一下啊？8 T% I. y! X& O
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另外：从方法学上，除了抗5-hmc的抗体可以分析5-hmc外，还有哪些文献报道了相关的分析方法？欢迎大家汇总。

fwyou

好像缺几篇文献吧
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' V8 Y; {7 v  m8 p+ z/ dTet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development.Cell Stem Cell. 2011 Aug 5; 9(2): 166-75
0 i0 c3 _- H5 U  Y2 V: B& o. HGenome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells.Mol Cell. 2011 Apr 20;
$ G4 O% [# f9 _$ {, ^; eGenome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.Genes Dev. 2011 Apr 1; 25(7): 679-84
& [- q4 U1 ?( `3 ]9 G, x3 O都没有啊) _& O3 O/ B8 }& Q2 U" g/ V
版主，你有没？
8 r" ?: _- ]4 B! ~或者群友别人有没》？

yeya

我来上传吧。貌似生化所最近SCIENCE也有发Tet

xlwhzp

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- Z/ S" X: s4 U4 W9 X' pscience上最新的两篇文章及supplementary material; `4 f* x0 R) ^6 H
cell stem cell 上有最新的一篇文章关于干细胞和5hmC的，链接是http://www.sciencedirect.com/science/article/pii/S1934590911003407，

游侠儿2012GX

我这里也有几篇，供大家参考( R; u* v, n, S
TET Genes: new players in DNA demethylation and important determinants for stemness, Experimental Hematology 2011;39:272–281
& I7 p# _( W2 [: q! N% yTET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity,1 9 M AY 2 0 1 1 | VO L 4 7 3 | N AT U R E | 3 4 3
( O; o: U+ N, h  K  R6 ?Tet1 and Tet2 Regulate 5-Hydroxymethylcytosine% }) N* Q1 \4 P  l4 R+ Z0 c/ ?8 C: o
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes

游侠儿2012GX

我在一篇文章里面看到Ayu17-449, a novel gene on mouse chromosome 3, was identified by the gene trapping technique previously reported by Tang et al. (2006). In NCBI database analysis, Ayu17-449 is also called TET-2 (tet oncogene family member 2). It belongs to a novel, well-conserved, protein family but with unclear biological function, the TET protein family, including three members (TET-1, TET-2 and TET-3). 不知道这tet2是不是Ayu17-449