- 积分
- 219
- 威望
- 219
- 包包
- 2027
|
本帖最后由 如来的观音 于 2011-2-24 21:14 编辑
. x& L( G7 B: _1 {) L2 C* ~
9 E5 O; y0 L; y. G" zThe central nervous system has limited capacity of regenerating lost tissue in slowly progressive, degenerative neurological conditions such as Parkinson’s disease (PD), Alzheimer’s disease or Huntington’s disease (HD), or in acute injuries resulting in rapid cell loss for example, in cerebrovascular damage (for example, stroke) or spinal cord injury. Although the adult brain contains small numbers of stem cells in restricted areas, they do not contribute significantly to functional recovery. Transplantation of stem cells or stem cell-derived progenitors has long been seen as a therapeutic solution to repair the damaged brain. With the advent of the induced pluripotent stem cells technique a new and potentially better source for transplantable cells may be available in future. This review aims to highlight current strategies to replace lost cellular populations in neurodegenerative diseases with the focus on HD and PD and traumatic brain injuries such as stroke, discussing many of the technical and biological issues associated with central nervous system cell transplantation.
% r# O- L" A" m; R. `在缓慢进展的退行性神经系统疾病如帕金森病PD、阿尔茨海默病或亨廷顿病HD,或急性脑损伤导致的急性脑细胞死亡(如脑血管损伤或脊髓损伤)中,中枢神经系统只有有限的再生能力。虽然成人脑在限制性区域有少部分的干细胞,但是他们对于功能的恢复却没有太大的意义。干细胞的移植或干细胞来源的母细胞移植被视为修复脑损伤的治疗手段。随着诱导多能干细胞技术的问世,在将来可能提供更好的移植细胞来源。这篇综述的目的在于突出当今的战略,以修复HD,PD和中风等创伤性脑损伤方面的神经退行性疾病而损伤的细胞群,并讨论与中枢神经系统细胞移植相关的技术和生物学方面的许多问题。 |
附件: 你需要登录才可以下载或查看附件。没有帐号?注册
-
总评分: 威望 + 15
包包 + 30
查看全部评分
|