干细胞移植用于肝再生治疗的相关研究进展

guokeyi

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刘晓珑　李波
6 J3 k" l, W& O/ b, i: n. k5 `　　【摘　要】　　目的　对干细胞移植应用于肝再生治疗的相关研究进展进行综述。　方法　广泛查阅近年的相关文
9 Y5 z& y  K# R. y8 }献, 对移植研究中常见的干细胞类别、修复机制、植入途径以及临床相关问题进行综述。　结果　修复肝脏的干细胞可以8 G& G8 v7 D0 Z  Q
分为肝源性干细胞和非肝源性干细胞; 修复机制主要是融合或转分化; 植入途径以门脉内植入多见。目前仍有许多临床
) z6 ?& _+ \7 [$ S! `; {  s; c相关问题限制干细胞移植的应用。　结论　提高干细胞的临床实用性需要更深入的研究。
. a( @7 @3 t$ ^! I( |9 M$ C1 i【关键词】　　干细胞　　再生医学　　肝脏  }) I3 l1 A% b2 @6 D
中图分类号: Q 813　R65713　　文献标识码:A
3 j- k% \+ v9 s2 _DEVELOPMENTOF L IVER STEM CELL TRANSPLANTATION FOR L IVER REGENERATIVE TREATMENTöL IU
- }1 z' ~! C; I) Y- y" eX iaolong , L I B o. D ep artm ent of General S u rg ery , W est Ch ina H osp ital, S ichuan U niversity , Cheng d u S ichuan,- `2 [$ M- m- }6 v4 G
610041, P. R. Ch ina. E 2m ail: g x lliu@126. com8 ?+ t# a# a' }5 w- |9 u
Corresp ond ing au thor: L I B o, E 2m ail: cd libo@m edm ail. com. cn
# _* X3 [+ }" S【Abstract】　　Objective　To review the development of the liver stem cell t ransp lant fo r the liver regenerat ive4 R! t  r; T; G4 y7 {( w
t reatment. 　Methods　The t ransp lantat ion2related art icles about the stem cell classificat ion, repairing mechanism s,
1 N4 K& ^+ {9 X, B* \* v, }adm inist rat ion routes, and exist ing p roblem s in the liver regenerat ive therap ies repo rted in the latest literature w ere
3 K* D: S  u/ B# O2 Wextensively review ed. 　Results　The related liver2repairing stem cells w ere found to be inside and outside the liver,
3 _2 M& N/ [( U+ ^4 _i. e. , the hepat ic stem cells and the non2hepat ic stem cells. They could repair the liver by the mechanism of the cell, J0 V- s% K3 m- b- I8 O
fusion o r the cell t ransdifferent iat ion. The stem cells could be adm inist rated via the po rtal vein. How ever, the( K7 H& ^' u) U8 u2 c
app licat ion of the liver stem cell t ransp lant w as rest ricted by many related clinical p roblem s. 　Conclus ion 　Further
+ m8 r8 i: p0 t/ v4 @6 xstudies are st ill needed fo r an imp rovement of the clinical feasibility fo r the stem cell t ransp lantat ion, especially fo r the% T  o' v4 ?# W+ T$ ~; X6 Z: q3 q
liver stem cell t ransp lantat ion.
8 e$ f5 R! w: v- z/ Z【Key words】　　Stem cell　　Regenerat ive medicine　　L iver) K4 L! V8 }, R2 q

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