干细胞分化中的重要调控信号通路：报道与实例

kephort

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+ a1 @  d( |* @; e, x$ {3 a8 y8 b对于干细胞的研究，如果不深入研究调控的话，很难有story或good idea，欢迎大家就这方面进行讨论和分析。* J0 O8 H. u! Y1 ?( @$ ^
1、干细胞分化中的重要调控信号通路Wnt/beta-Catenin
# B, T) q# f* n7 kWnt/beta-Catenin信号通路在干细胞分化、癌症发生等都有着重要作用，对这方面的重要文献和关注度高的高引用文献分享给大家。也提供了相关的全文，欢迎下载。
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+ W  d5 J3 R3 k& u5 e1.        MacDonald, B.T., K. Tamai, and X. He, Wnt/beta-Catenin Signaling: Components, Mechanisms, and Diseases. Developmental Cell, 2009. 17(1): p. 9-26.; ^# a8 N7 J) a* h& `
2.        Michaelidis, T.M. and D.C.C. Lie, Wnt signaling and neural stem cells: caught in the Wnt web. Cell and Tissue Research, 2008. 331(1): p. 193-210.0 @: R) {$ m. e9 ~5 g9 ~
3.        Klaus, A. and W. Birchmeier, Wnt signalling and its impact on development and cancer. Nature Reviews Cancer, 2008. 8(5): p. 387-398.2 r7 n: u+ z; h" C, |3 J
4.        Giles, R.H., J.H. van Es, and H. Clevers, Caught up in a Wnt storm: Wnt signaling in cancer. Biochimica Et Biophysica Acta-Reviews on Cancer, 2003. 1653(1): p. 1-24.5 C4 c* V; C# p. j" p$ e
5.        Polakis, P., Wnt signaling and cancer. Genes & Development, 2000. 14(15): p. 1837-1851.
" d" J2 b: S0 N3 L6.        Tetsu, O. and F. McCormick, beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature, 1999. 398(6726): p. 422-426.- m% u5 v6 R, v% h; }  C3 [$ Z
7.        Cadigan, K.M. and R. Nusse, Wnt signaling: a common theme in animal development. Genes & Development, 1997. 11(24): p. 3286-3305.+ ~# B4 S8 W% R; Q) O) A3 C
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七篇文献全文请在附件中下载。
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$ M  r+ H0 d8 F; `8 j2 p后续的帖子中将对干细胞分化过程中的各个信号通路、表观遗传调控进行汇总。7 T9 t8 @. w! q! V7 i- W
也欢迎大家发表自己的观点，补充各个regulation pathways。

痞子的烟头

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8 r4 t  ?" A* [5 f谢谢海洋$ o; X. O5 H" @0 j( U7 i

% w2 J, v7 G( b. J海洋注：怎么谢我了？kephort 的原创呀

jiandong2001

谢谢分享

kephort

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2、polycomb 和 trithorax（protein）在干细胞的分化及分化中的多种表观遗传修饰发挥着重要调控作用，下面是这些基因和调控信号通路相关的重要文献：
. q" _; {" a3 X4 Q  B, ~4 k1.        Simon, J.A. and R.E. Kingston, Mechanisms of Polycomb gene silencing: knowns and unknowns. Nature Reviews Molecular Cell Biology, 2009. 10(10): p. 697-708.. t0 I! R. u- x$ Q! A8 {  X/ h
2.        Schuettengruber, B. and G. Cavalli, Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice. Development, 2009. 136(21): p. 3531-3542.
# b. Z8 U  T. s3.        Kerppola, T.K., Polycomb group complexes - many combinations, many functions. Trends in Cell Biology, 2009. 19(12): p. 692-704.$ n# s6 C# z7 l( D7 u9 w& M$ x& T
4.        Schwartz, Y.B. and V. Pirrotta, Polycomb silencing mechanisms and the management of genomic programmes. Nature Reviews Genetics, 2007. 8(1): p. 9-22.
1 h) n! a( C' u8 }+ r. O  Y5.        Schuettengruber, B., et al., Genome regulation by polycomb and trithorax proteins. Cell, 2007. 128(4): p. 735-745.3 r9 z( ]% V" |
6.        Sparmann, A. and M. van Lohuizen, Polycomb silencers control cell fate, development and cancer. Nature Reviews Cancer, 2006. 6(11): p. 846-856.' G' R# c* k$ S3 _7 t1 F
7.        Muller, J. and J.A. Kassis, Polycomb response elements and targeting of Polycomb group proteins in Drosophila. Current Opinion in Genetics & Development, 2006. 16(5): p. 476-484.6 P& q4 W3 X4 L0 ^
8.        Bracken, A.P., et al., Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes & Development, 2006. 20(9): p. 1123-1136.
& I  y( ~+ \, O" A4 z9.        Boyer, L.A., et al., Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature, 2006. 441(7091): p. 349-353.
3 w% D( t% }% D, E4 a10.        Bantignies, F. and G. Cavalli, Cellular memory and dynamic regulation of polycomb group proteins. Current Opinion in Cell Biology, 2006. 18(3): p. 275-283.
2 w; V" G. ~' U' I2 I2 z11.        Levine, S.S., I.F.G. King, and R.E. Kingston, Division of labor in Polycomb group repression. Trends in Biochemical Sciences, 2004. 29(9): p. 478-485.& s' w- C, q/ S1 l% o# _& y9 u
12.        Lessard, J. and G. Sauvageau, Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis. Experimental Hematology, 2003. 31(7): p. 567-585.  u3 M6 O) @% C+ O/ S4 O
13.        Simon, J.A. and J.W. Tamkun, Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes. Current Opinion in Genetics & Development, 2002. 12(2): p. 210-218.) B, o8 Q) e5 ~& r( q; O! m2 [
14.        Schumacher, A. and T. Magnuson, Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends in Genetics, 1997. 13(5): p. 167-170.9 Z% {4 S! y( t* f
也打包提供了全文。" b4 Z! a+ B- \3 F
请下载附件中的14篇全文PDF
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kephort

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9 b3 U. G3 V4 a. m) Q欢迎大家关注、讨论细胞分化和细胞命运决定的机制。
; x* b- a, ~7 Y1 L也可以就你对这方面的调控机制（细胞信号通路或表遗传修饰）、存在的问题展开讨论，谢谢！! _, n% p& }" a" ^. f9 M
感兴趣的朋友不要忘了你也可以来评分的，请加包包或威望来捧场啊，本帖后续主题也全部免费下载。

show0ji3

最近也正想看看有关细胞通路的文献，谢谢您的帖子。

tspaulzhao

很好的建议，也谢谢你的分享。

lorey

谢谢分享！

Sophia

正在看信号通路方面文献，这些真是太好了，非常感谢！

dulaiyouyu

还有Notch通路。还没有像楼主一样整理多篇相关文献。呵呵。