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本帖最后由 marrowstem 于 2016-3-15 21:26 编辑
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6. 2015年3月5日,Cell Stem Cell以封面文章的形式发表了中国科学院动物研究所周琪课题组与中国科学院基因组研究所杨运桂课题组、中国科学院遗传与发育生物学研究所王秀杰课题组合作,整合各自在干细胞、RNA修饰、高通量数据分析方面的研究优势,绘制了小鼠胚胎干细胞 (ESC)、诱导多能性干细胞 (iPSC)、神经干细胞 (NSC)和睾丸支持细胞 (SC) 转录组的m6A修饰图谱,发现了m6A修饰在多能与分化的细胞系间的分布差异,和发生在一些决定细胞特异分化的RNA分子上的细胞类型特异的m6A修饰。
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On the cover: In this issue, Chen et al. (289–301) show that m6A modifications on mRNAs are enriched at microRNA target sites, the formation of m6A modification is regulated by microRNAs via a sequence pairing mechanism, and increased m6A formation promotes cell reprogramming to pluripotency. The cover art depicts the formation of m6A on mRNA sequences. m6A (the fire) is formed on adenosine (the beacon towers) within the RRACH motif, with the help of microRNAs (the firewood). The image was designed by four of the authors, Tong Chen, Xiu-Jie Wang, Yun-Gui Yang, and Qi Zhou, who would like to thank Gui-Hai Feng for inspiring discussions and Jessica Tang for the image creation. |
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