- R) d/ }) ? a5 o2 k7 t" [/ IVolume 38, Issue 5) w$ P* _3 o+ G& [4 @3 i4 x
On the cover: Regulation of metabolic pathways in the immune system provides 1 d/ ?$ Z3 W- t+ W" d2 J
a mechanism to actively control cellular function, growth, proliferation, and 6 A3 v3 Y8 n) b8 [1 K' Q7 wsurvival. However, the contribution of microRNAs to the regulation of cellular , v3 @) y% K8 Ametabolism in the immune system is unclear. In this issue of Immunity, 2 t7 e. D4 z1 R$ @+ f+ @" rHenao-Mejia et al. (984–997) show that the miR-181 family is a critical * |# K& f+ o, \! _. L/ t
determinant of cellular metabolism, and therefore it is essential to support the 8 v% @$ P' x0 ?$ N
high biosynthetic demands of lymphocyte development. In particular, regulation 7 c; _& U6 g" d; X; v) j8 f
of cellular metabolic pathways by miR-181 is absolutely required for early 2 p2 B* S: W* C8 q
natural killer T cell development. The cover cartoon depicts a lymphocyte that 6 [7 {; N1 U9 M
necessitates the presence of miR-181 (represented as an electrical plug) to 9 I, T- x2 n3 A6 a
maintain a robust metabolism. Thus, in the absence of miR-181 (unplugged 1 |9 ^) ]6 B( O/ ]7 Wstatus), the lymphocyte lacks the energy to efficiently carry out normal % h: Y. t- j' S5 E9 ~' V4 v: E
functions. Image created by Gustavo Zapata. 1 B) K. a& ], t0 g, _作者: yuheng 时间: 2013-5-24 21:18
