标题: 【重磅出击】NOVA-The ghost of your Gene [打印本页] 作者: Tlexander 时间: 2012-2-21 10:57 标题: 【重磅出击】NOVA-The ghost of your Gene
NOVA最经典的一批关于DNA methylation的电影集 1 }$ a9 x% L" Z4 c* |4 s( J1 K1 u; y1 M- v) i. }2 N http://www.pbs.org/wgbh/nova/programs/ 4 Q7 a, l5 D" `2 t7 m# \$ k7 ihttp://www.pbs.org/wgbh/nova/sea ... &y=11&facet2 y1 P1 J) `9 z; T
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海洋注：因为文件较大，为减轻服务器负担更改为仅限注册会员级别（威望大于50）下载，同时提示大家：禁止使用下载软件或者同时多个附件下载，必须使用浏览器默认单线程下载，下载完成一个再下载下一个，望理解） 2 k# ^% [/ B- eDNA methylation is a biochemical process that is important for normal development in higher organisms. It involves the addition of a methyl group to the 5 position of the cytosine pyrimidine ring or the number 6 nitrogen of the adenine purine ring (cytosine and adenine are two of the four bases of DNA). This modification can be inherited through cell division.! }7 L8 c* \& Q* T; s' Q
DNA methylation is a crucial part of normal organismal development and cellular differentiation in higher organisms. DNA methylation stably alters the gene expression pattern in cells such that cells can "remember where they have been" or decrease gene expression; for example, cells programmed to be pancreatic islets during embryonic development remain pancreatic islets throughout the life of the organism without continuing signals telling them that they need to remain islets. DNA methylation is typically removed during zygote formation and re-established through successive cell divisions during development. However, the latest research shows that hydroxylation of methyl group occurs rather than complete removal of methyl groups in zygote.[1] Some methylation modifications that regulate gene expression are inheritable and are referred to as epigenetic regulation. 1 b- l+ S0 ^' S; j JIn addition, DNA methylation suppresses the expression of viral genes and other deleterious elements that have been incorporated into the genome of the host over time. DNA methylation also forms the basis of chromatin structure, which enables cells to form the myriad characteristics necessary for multicellular life from a single immutable sequence of DNA. DNA methylation also plays a crucial role in the development of nearly all types of cancer.[2]: d2 x/ O5 j! P; T$ a) X! x1 y! X
DNA methylation at the 5 position of cytosine has the specific effect of reducing gene expression and has been found in every vertebrate examined. In adult somatic tissues, DNA methylation typically occurs in a CpG dinucleotide context; non-CpG methylation is prevalent in embryonic stem cells.4 Z7 d( n& F; W- e7 @
J8 l; R6 M. Q( a; @ 作者: bridgeyangfan 时间: 2012-2-21 11:54
