据日本东京《每日新闻》和澳大利亚新闻网12月8日消息，日本科学家日前向外界宣布一项重大实验结果：通过干细胞治疗方法使一只高位截瘫的猴子恢复健康。这是干细胞疗法首次应用于灵长类动物，并取得突破性进展。+ s/ I) \3 K3 X$ k. Z+ ~
0 x! i7 S) _3 d日本庆应义塾大学的研究人员将一只自脖子以下全部瘫痪的猴子作为实验对象，将4对基因注入事先提取出的人类皮肤细胞中，培养出了诱导性多潜能干细胞，在猴子瘫痪第9天的时候将这种诱导性多潜能干细胞注入猴子的脊柱中。“第9天”这个时间点是研究人员认为最佳治疗时间。该大学生理系教授冈野荣之介绍，约2-3周后，这只猴子的四肢逐渐可以运动，慢慢恢复了行走能力。约6周后，这只猴子已经可以自如地跳动，其行动能力与受伤前差别不大。 " u. g9 B# {! z, K- R! @ 8 R9 w% {$ d. `% T& e冈野荣之教授接受采访时表示，这是人类首次将干细胞疗法应用在脊柱受损的小型灵长类动物身上，并获得明显疗效。这项实验也为未来应用于人类的临床治疗铺平了道路。此前，庆应义塾大学曾与京都大学联合实验，通过诱导性多潜能干细胞注入，使一只脊髓受损的老鼠恢复了行动能力。 $ N! [# G1 [0 ~4 l 6 ?9 Y' E/ |' ]. n- ]. c8 o- U据悉，虽然实验的意义重大，但何时能应用于人类还不好说。胚胎干细胞研究过程中往往会破坏人类胚胎，相关研究仍然在世界范围内饱受争议。（生物谷Bioon.com）4 P' {" y: ]+ @6 s
% \ C9 a5 \4 X! G 作者: qingshui1985 时间: 2010-12-10 09:05
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英文稿件： - h$ B( [' t4 @/ o/ SA young marmoset is carried by its father at the Amneville zoo, eastern France, June 2010. Japanese researchers said Wednesday they had used stem cells to restore partial mobility in a small marmoset that had been paralysed from the neck down by a spinal injury. 9 A+ F& z9 D) s + I0 Z! V! [$ T6 l% JJapanese researchers said Wednesday they had used stem cells to restore partial mobility in a small monkey that had been paralysed from the neck down by a spinal injury. / ?5 n' ? n6 s/ @$ F4 J/ W H8 S" A& @5 M; }3 u
"It is the world's first case in which a small-size primate recovered from a spinal injury using stem cells," professor Hideyuki Okano of Tokyo's Keio University told AFP. # @ e$ H4 s4 E4 `# F% o # r9 \5 Q# y! o8 p( a8 YOkano's research team, which earlier helped a mouse recover its mobility in a similar treatment, injected so-called induced pluripotent stem (iPS) cells into a paralysed marmoset, he said. , s" ]2 {$ A: |- O. v2 D # b8 H: B. S8 b/ j- G8 l" t9 ]5 xThe team planted four types of genes into human skin cells to create the iPS cells, according to Kyodo News. 0 w* m# a! m& R " ^: a% m# e7 t% s3 |The injection was given on the ninth day after the injury, considered the most effective timing, and the monkey started to move its limbs again within two to three weeks, Okano said.! _7 [( _% @# u
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"After six weeks, the animal had recovered to the level where it was jumping around," he told AFP. "It was very close to the normal level."& L; A. U% u# H% Z9 D7 `
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"Its gripping strength on the forefeet also recovered to up to 80 percent."+ Y& |; N8 b1 i$ e6 }3 e) f3 g
# I" u' G) |/ C! }! B5 K6 o8 X/ M5 OOkano called the research project a major stride to pave the way for a similar medical technique to be used on humans.- D* }- [+ `7 i& J6 @, @
& H7 K! @+ R0 T) yScientists say the use of human embryonic stem cells as a treatment for cancer and other diseases holds great promise, but the process has drawn fire from religious conservatives and others who oppose it. # D3 U7 P/ d2 N+ G" f) w6 Q% K7 s8 G) Y1 i0 M
Embryonic stem cell research is controversial because human embryos are destroyed in order to obtain the cells capable of developing into almost every tissue of the body.; e; L) F R# n
1 p& [& M5 ^# { 作者: 痞子的烟头 时间: 2010-12-10 09:21
本帖最后由 痞子的烟头 于 2010-12-10 09:29 编辑 4 B9 g$ P/ n" v2 K! B: O! }1 q( F! O8 a
胚胎干细胞何时能应用到临床，最初始的细胞不表达组织相容性复合物，但异体由于生物发育模式不同，在体内成熟过程，抗原会被识别，难免会产生免疫排斥；IPS先不说诱导方法，单是基因整合就有很大的危险性；现在市场临床治疗可以用的还只有成体干细胞，先不说安全性有效性如何，起码不会有危险；7 Q, K0 g) K i
期待下一步结果…… P- P* ~' M8 v; C8 m关注作者: qizhi502 时间: 2010-12-10 09:21
日本人 这个实验创新性很大。如果取的是猴子皮肤细胞然后ips，最后治疗了猴子截瘫。其实也可以的。0 n6 A- f" |, Q9 c( }6 t2 ]
但是他们用人的皮肤ips，治疗猴子截瘫，却更有意思了; J+ B' E y* M7 u
The team planted four types of genes into human skin cells to create the iPS cells, according to Kyodo News. w! U9 ]" X6 _2 T' N* o( Z : V4 q; L1 T/ g! EThe injection was given on the ninth day after the injury, considered the most effective timing, and the monkey started to move its limbs again within two to three weeks, Okano said.- D0 q; Q, l; f 作者: 千细胞 时间: 2010-12-10 12:36
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