本帖最后由 sunsong7 于 2017-3-26 23:37 编辑 % E. W. _" Z, L+ s4 _5 U$ v o+ @
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4月22日,《自然》刊登了加州大学旧金山分校(UCSF)Mark R. Looney教授团队动物体内有一半以上的血小板来自于肺部;发现肺部储存有多种造血祖细胞,这些细胞可以用于恢复受损骨髓的造血能力; ( o X! G7 z8 F7 K$ _' f1)肺部的巨核细胞和造血祖细胞源自骨髓;0 h/ }- }* X; t/ b( g& y 2)肺储存的造血祖细胞可以回到骨髓; 0 p8 [+ W k" I 1 F# H3 {8 P# R老狼推论: m" Y& Z) @# A Q0 i& y 1)肺并非真正的造血器官,肺部的毛细血管截留了外周血内的巨核细胞与造血祖细胞; % m- I2 y0 X1 d# M- @* ~2)动物体毛细血管丰富的器官具有同样功能,譬如:肌肉、肾脏、血脑屏障均具有“造血功能”;9 ~5 q8 ~5 q" v/ ]) q( h! c
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8 B" r: u5 l( S: X【1】Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, et al. 2017. The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors. Nature advance online publication ( w" i9 V4 d r8 _. q【2】Looney MR, Thornton EE, Sen D, Lamm WJ, Glenny RW, Krummel MF. 2011. Stabilized imaging of immune surveillance in the mouse lung. Nat Meth 8:91-6 3 k( p* m! N' x6 }* N& P【3】Machlus KR, Italiano JE. 2013. The incredible journey: From megakaryocyte development to platelet formation. The Journal of Cell Biology 201:785-967 c4 S) N& R3 J& @* p8 i
【4】Aschoff L. 1893. Uber capillare Embolie von riesenkemhaltigen Zellen. Arch Pathol Anat Phys 134:11-46 R& S" }. e( R! ?& F7 p2 q" N
【5】Howell WH, Donahue DD. 1937. THE PRODUCTION OF BLOOD PLATELETS IN THE LUNGS. The Journal of Experimental Medicine 65:177-203 $ d4 m+ y" M$ a) ?2 @- Y【6】http://www.ucsf.edu/news/2017/03 ... -lungs-making-blood 5 Y' j4 M- _ B J- s( m' Y) J( a' k
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