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2013-7-26 Science3 _" A( q* F7 P0 h" b1 C% `7 C
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COVER Immunostained fluorescence microscopy image of memory
+ q5 z1 Y' d" a. k1 }7 ^" G- \* ]! Aengram–bearing cells (red) in the dentate gyrus of a mouse hippocampus (image 5 P$ z5 v; T! Q5 x: b6 [; z1 k
width: 1.5 millimeters). These cells were genetically tricked to express the 7 s, _8 d/ l6 T7 r* y4 o; }
protein channelrhodopsin-2 during memory formation, thus becoming responsive to
% _) b; L' R+ {- l+ S& R2 elight stimulation. When the cells were activated by light, the mice
b( N. ?9 G' j6 Hsimultaneously associated a genuine memory with an undesirable event (a foot
; a1 S, L- L4 ^shock) to create a new but false memory. See page 387. Image:
6 N# n8 S( t4 d4 d6 fXu Liu and Steve Ramirez
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