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本帖最后由 kephort 于 2010-5-27 12:41 编辑 ; J) ]" x6 y* O, z
# ~+ }' G: H/ F, Y2、polycomb 和 trithorax(protein)在干细胞的分化及分化中的多种表观遗传修饰发挥着重要调控作用,下面是这些基因和调控信号通路相关的重要文献:
8 y W ?4 F( a1. Simon, J.A. and R.E. Kingston, Mechanisms of Polycomb gene silencing: knowns and unknowns. Nature Reviews Molecular Cell Biology, 2009. 10(10): p. 697-708.; D9 I) P7 T t/ P* K [. {
2. Schuettengruber, B. and G. Cavalli, Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice. Development, 2009. 136(21): p. 3531-3542.
2 J& B3 \: y7 I, _ e/ B3. Kerppola, T.K., Polycomb group complexes - many combinations, many functions. Trends in Cell Biology, 2009. 19(12): p. 692-704.
' [6 h4 M1 P2 f- m4 f4. Schwartz, Y.B. and V. Pirrotta, Polycomb silencing mechanisms and the management of genomic programmes. Nature Reviews Genetics, 2007. 8(1): p. 9-22.1 v5 }$ L: A) n
5. Schuettengruber, B., et al., Genome regulation by polycomb and trithorax proteins. Cell, 2007. 128(4): p. 735-745.+ p, u( B! {1 P+ p0 P1 n
6. Sparmann, A. and M. van Lohuizen, Polycomb silencers control cell fate, development and cancer. Nature Reviews Cancer, 2006. 6(11): p. 846-856.0 q6 |. g3 a a; K0 Q: x
7. Muller, J. and J.A. Kassis, Polycomb response elements and targeting of Polycomb group proteins in Drosophila. Current Opinion in Genetics & Development, 2006. 16(5): p. 476-484.
, F8 w6 \& m! M! v: |8. Bracken, A.P., et al., Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes & Development, 2006. 20(9): p. 1123-1136.) |4 q- I& T9 f2 H, w
9. Boyer, L.A., et al., Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature, 2006. 441(7091): p. 349-353.3 `, F$ f0 L. i4 s% @$ L
10. Bantignies, F. and G. Cavalli, Cellular memory and dynamic regulation of polycomb group proteins. Current Opinion in Cell Biology, 2006. 18(3): p. 275-283.
4 l3 o! j0 d; f2 ?% P% |+ N# ^) _11. Levine, S.S., I.F.G. King, and R.E. Kingston, Division of labor in Polycomb group repression. Trends in Biochemical Sciences, 2004. 29(9): p. 478-485.$ J F- o- ^, q1 P3 }
12. Lessard, J. and G. Sauvageau, Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis. Experimental Hematology, 2003. 31(7): p. 567-585.: z' o& E. | t$ U* ]
13. Simon, J.A. and J.W. Tamkun, Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes. Current Opinion in Genetics & Development, 2002. 12(2): p. 210-218.
0 D% W7 i/ u9 O# t) V6 Y5 _, \; K! {4 k14. Schumacher, A. and T. Magnuson, Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends in Genetics, 1997. 13(5): p. 167-170.
! k( w) T3 ~, K% m: L& F) E也打包提供了全文。
/ [& E# e# V% _, \* X m% }! o请下载附件中的14篇全文PDF3 h$ A& V+ o- c/ R' Y' u% @
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