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 0 t' B* w n1 q
COVER Structure of the Wnt signaling molecule (red) in complex with # {2 g4 S- |. D% Q( M0 k: V3 ]6 b
the Frizzled ligand-binding domain (yellow), schematically depicted as connected
7 M1 O' w3 c t, @to the cell surface. A key feature of this structure is the visualization of a $ u2 l# f* [" P: y1 S, f ~" K
lipid group (blue) on Wnt directly engaging Frizzled. The Wnt/Frizzled mode of
8 P* |9 a2 @* Abinding paves the way for the design of Wnt-based therapeutics. See page 59. Image - ~; i U: `& Y2 ?5 E8 _
produced by Eric Smith and Chris Garcia
3 O% ]3 k0 S# v; g: A- o5 r[hide][/hide] |
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发表于 2012-7-6 23:39
发表于 2012-7-7 08:53
