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Many growth factors that promote the formation of bone-forming cells called osteoblasts are thought to act through a transcription factor called core binding factor 1 (Cbfa1). Mice lacking Cbfa1 fail to form any mature osteoblasts or bones, and experiments with a dominant negative form of Cbfa1 have suggested that the protein is important in regulating osteoblast functions such as matrix formation and mineralization.
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Now, Liu et al. (page 157) find that mice overexpressing Cbfa1 in their osteoblasts have weak bones and multiple fractures within a few weeks after birth. Immature osteoblasts accumulate, suggesting that the excess Cbfa1 inhibits a late stage of osteoblast maturation. Thus, Cbfa1 is essential early in maturation but must then be downregulated to allow final maturation.(More marrow and weaker bones in mice wit) |
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发表于 2009-3-5 23:32
发表于 2015-6-6 16:20
