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Strongly recommend this "old" paper.( p0 v- v }7 O; X* ]# v. _. S7 U
, B+ b8 ^% c+ m' Z3 u& W
8 a, v! c! P! sA Cup Half Empty or Half Full?8 N, o! u, f8 x, c5 N
George Q. Daley
- g% Q5 [! f* b q4 H# k& [/ D$ zAbstract,) L$ R' b+ t8 L- w2 y! _) }
When first reported 4 years ago, gametogenesis from embryonic stem (ES) cells promised an0 L- O. p; h \7 @5 }2 H- o9 o# [
accessible in vitro model to facilitate molecular analysis of the germ lineage. Formation of
* u9 i, |/ \) bprimordial germ cells is robust, but terminal gametogenesis remains inefficient and doubts7 V0 Y/ {, f, K* a$ i3 ]' z& C
about gamete function persist. Although useful for research, clinical use of ES cell–derived
7 R2 r" y& m+ b+ Ggametes appears a distant prospect. |
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发表于 2010-6-10 09:29
发表于 2010-8-2 16:17
