美国UCLA大学斥资2000万美元建立干细胞研究所

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日期: 2005-03-18 今日/总浏览: 1/11502 {1 \, y9 j/ V) T4 s1 k& I

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UCLAlaunches$20millionstemcellinstitutetoinvestigateHIV,cancerandneurologicaldisorders
/ x# \$ K5 h- uExpertsinbioengineering,imaging,moleculargenetics,immunology,ethics,hematology/oncologyandcellularbiologytocollaborateonProposition71research
: |: e. U4 P6 uExpertsinbioengineering,imaging,moleculargenetics,immunology,ethics,hematology/oncologyandcellularbiologytocollaborateonProposition71research( I. I$ E1 R$ H2 T1 ]
Drawingtogetherexpertsfromfieldsasdiverseasengineeringtomolecularbiology,UCLAofficialsannouncedMarch16theformationoftheInstituteforStemCellBiologyandMedicinetoconductembryonicandadultstemcellresearchthatmayleadtobettertreatmentsforHIV,cancerandneurologicaldisorders.+ j" O9 R. B4 h6 S+ b. U* w
Asoneoftheworld’sleadingresearchuniversities,UCLAhaslongbeenengagedinadultandembryonicstemcellresearchwithactivitiesinareasrangingfromtheAIDSInstitutetotheBrainResearchInstitutetotheUCLACollege,saidUCLAChancellorAlbertCarnesale.ThenewUCLAInstituteforStemCellBiologyandMedicinewillenableustocontinuefosteringsuchinterdisciplinarycollaborationsandtobuildupontheexistingbodyofknowledgeforthebenefitofpeopleworldwide.
7 Y& Y, I0 j3 \/ lUCLAwillprovide$20millionoverfiveyearstolaunchthecampuswideinstitute,whichwillenableteamsofresearcherstocompeteforstategrantscreatedbythepassageofProposition71.Themoneywillpayforrecruitmentforadozennewfacultypositions,salariesandexpansionofhighlysophisticatedlaboratoryspace,infrastructure,andsupplies.
" |- i+ }. x9 n3 s6 NDr.OwenWitte,arenownedscientistwhoselaboratoryresearchlaidthegroundworkfordevelopmentofthetargetedleukemiatherapyGleevec,isdirectorofthenewinstitute.Healsostressedtheinterdisciplinaryapproachnecessarytofacethechallengesrelatedtostemcellresearch.Embryonicstemcellshavethepowertodevelopintoeverytypeofhumantissue,saidWitte,whoalsoisaprofessorofmicrobiology,immunologyandmoleculargenetics,andaHowardHughesMedicalInstituteinvestigator.Ifwecanlearnhowtheyareregulatedforgrowthanddevelopment,wecanharnessthisknowledgetostudytissuedevelopmentandregenerationandpotentiallycomeupwithnewwaystofightmanylife-threateningdiseases.+ I8 \4 H* J0 i9 Q7 n3 c1 c/ t; ~
ResearchersarehopefulthatstemcellresearchwillleadtorevolutionarynewtreatmentsforParkinson’s,spinalcordinjuries,Alzheimer’s,cancerandotherdiseases,andperhapsshednewlightonhowsomediseasesdevelop.However,mostscientistsagreethathumantreatmentsareyearsorevendecadesaway.6 c0 u" e% e# U1 [; R5 F
Proposition71,passedby59percentofCaliforniavotersinNovember,willprovide$3billionforstemcellresearch.AstateinstituteisbeingcreatedinNorthernCaliforniatoallocatefundingtostemcellscientistsatuniversities,medicalschoolsandresearchfacilities.GrantapplicationswillbeavailableinMay.A29-memberoversightandgoverningboardwilloverseetheinstituteandreviewrequestsforfunding.
& w0 f  I% l; wWiththelaunchofthisinstitute,werealizeourgoalofbringingtogetherscientific,ethical,legalandpolicyexpertsfromacrosstheUCLAcampustofocusonthegreatpromiseofstemcellresearch,saidDr.GeraldS.Levey,vicechancellorformedicalsciencesanddeanoftheDavidGeffenSchoolofMedicine.Asdean,Iamcommittedtoadvancingthefullpotentialofstemcellresearchtofindnovelandmoreeffectivetherapiestotreatmanydiseasesforwhichpresent-daytherapyiseitherunsatisfactoryorunavailable.% Z- G, b" e* k
BecausetheuniversityandmedicalschoolatUCLAarelocatedonthesamecampus,researchersarewellpositionedtocompeteforstemcellgrantfunding,Wittesaid.UCLAresearchershaveproventheirskillatusheringscientificdiscoveriesfromthelabtomodernmedicine.SeveraltargetedtherapiesweredevelopedbasedonUCLAresearch,includingGleevecandthebreastcancerdrugHerceptin.Additionally,UCLAscientistsplayedkeyrolesintestingthetargetedtherapiesAvastinandTarceva.: p9 a# @" I4 p& j; r7 k- Y2 c/ y
UCLAalsoistheonlypublicuniversityinCaliforniatoboastasophisticatedGoodManufacturingPractice(GMP)suite,aspecializedlaboratorythatiscriticalforthesafegrowthandmanipulationofstemcelllines.ComplianceofficersoverseeallresearchintheGMPsuite,whichmustfollowstringentfederalguidelinesforreintroductionofmanipulatedcellsintothehumanbody.
1 Y* U! `1 f' j. b" cInaddition,UCLA’sJonssonCancerCenterfeaturesanestablishedclinicaltrialsinfrastructurethatcouldbeusedtotestnewtherapeuticsthatmaydevelopasaresultofthestemcellstudies,saidJudithC.Gasson,cancercenterdirector,stemcellinstituteco-director,andaprofessorofmedicineandbiologicalchemistry.# K. J( [. S7 q$ H& S3 F( P, j
Iseecancerandstemcellsastightlylinked,Gassonsaid.Moreandmoreevidencesuggeststhatcancerisastemcelldisease.Manyofourcurrenttherapiesarenoteffectivebecausetheydon’ttargetthecancerstemcells.OurexperiencewithgenemedicineandtheGMPfacilitieswillmakeiteasierforustotranslateourbasicstemcellresearchintohumantherapiesbyusingfacilitiesandproceduresalreadyinplace.
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TheUCLAInstituteforStemCellBiologyandMedicinewillfocusitsembryonicandadultstemcellresearchinthreeareas:
% M' t( S( S! \6 f; @HIV:UCLAscientistsareexploringhowtheAIDSvirusblocksstemcellfunction,aswellasstemcellapproachestocombatingHIVdisease.Onepotentialtherapeuticexampleincludesinsertingantiviralgenesintoblood-formingstemcellsandreintroducingthemintothebody.Asthesebloodcellsdevelop,thegeneprotectsthematurecellagainstHIVinfection.TheUCLAAIDSInstitutealreadyhascompletedaPhaseIclinicaltrialusingadultstemcells.Embryonicstemcellsalsocouldbeengineeredforthisstrategytoavoidtheneedforisolatingpatients’cells,easetransplantationandincreaseclinicalusefulness.
: y7 Q# l( s  q2 @9 X& uCancer:Researchwillseektoshedmorelightoncancerstemcellsandhowtheydevelop.Notmuchisknownaboutcancerstemcellsandnewfindingsmayleadtotherapiesthattargetcellsignalingpathwaysspecificforcancerstemcells.Thesetherapieshoneinonwhatisbrokeninacancercellwhileleavingthehealthytissueintact.SeveralJonssonCancerCenterresearchersalreadyaredoingstemcellresearchinlaboratories,andthatworkwillbefoldedintotheinstitute.
* ]" @) x0 X) gNeurologicaldisorders:UCLAresearchersarestudyingmanyaspectsoftherolesthatstemcellsmayplayinhealingneurologicaldisorders,includingstroke,spinalcordinjury,braintumors,multiplesclerosisandgeneticdiseases.Futurestudieswillincludeinvestigationofstemcellbiologyanddevelopment,aswellastherapeuticbasedresearchusingadultandembryonicstemcells.
) m& h: t% Z1 v3 Z, Q6 q/ wTheInstituteforStemCellBiologyandMedicineisacollaborationoftheDavidGeffenSchoolofMedicine,UCLA’sJonssonCancerCenter,theHenrySamueliSchoolofEngineeringandAppliedScience,andtheUCLACollege.Eachcollaboratorbringsleading-edgetechnologiestothetable:integratedmicrofluidicstoaidincellisolation,microarraysandshapeencodedparticleapproachesforgeneexpressionanalysis,proteomicsusingadvancedmassspectroscopy,large-scalecomputationalfacilitiesforbioinformatics,andworld-classmultimodalityimagingfacilitiesforanalysisofstemcelltherapiesinlaboratorymodelsand,ultimately,inpatientsenrolledinclinicaltrials.3 w2 s. g  g' r/ p' I! k; q& A( E
UCLAencouragesstrongcollaborationsbetweenfacultyinthelifesciencesandthehealthsciences,saidPatriciaO’Brien,executivedeanoftheUCLACollege.Asbiomedicinegrowsincreasinglycomplex,newacademicpartnershipsholdthekeytodiscovery;thisinstitutewillcreatenovelopportunitiesforresearchthatspansmanydisciplines.5 H: i2 N  s; `: Y& K

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- |$ q" l0 F1 B/ V6 f来源: eurekalert.org3 ~% y. N- Q* I" ~
发布者: 刘斌