PDF电子书：PROTEIN ENGINEERING （2012）

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PROTEIN ENGINEERING! H! A1 u' c) o1 E0 U  U) [% g
Edited by Pravin Kaumaya) _! W& i4 O4 ]; q% p
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Copyright © 2012 InTech
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! `: o8 y( t; K& v: ?Contents/ k- J! \" Q) D  F
Preface   IX7 _9 j9 x) ?' P8 [
Chapter 1   Structure-Functional Insight Into Transmembrane Helix Dimerization   1
: S9 q% a% d  F' }, J5 SEduard V. Bocharov, Konstantin V. Pavlov, Pavel E. Volynsky, Roman G. Efremov and Alexander S.
0 R! o" |4 O6 |. r1 o3 Q2 BArseniev
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Chapter 2    Protein Engineering Methods and Applications   33
' Z& ]* q* Y/ \2 O2 KBurcu Turanli-Yildiz, Ceren Alkim and Z. Petek Cakar* y! o3 L$ j6 ^/ D: N4 ~3 }
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Chapter 3   Evolutionary Engineering of Artificial Proteins with Limited Sets of Primitive Amino
/ F5 o* z* r/ O! r1 @: [6 e: }2 I; iAcids   59 Junko Tanaka, Hiroshi Yanagawa and Nobuhide Doi. u& M3 X) B$ `4 O

, o+ _( J. _  |! X1 y1 aChapter 4   Protein Engineering Applications on Industrially Important Enzymes:
: S9 P. b" b& I  T' X9 u  y5 JCandida methylica FDH as a Case Study    75
: m( Y3 n. G& P  [Emel Ordu and Nevin Gül Karagüler' P4 z6 g% C: d9 a5 w1 d4 Q/ Q) _

( m! ~/ f9 j- t8 N, ?, R% p$ a5 q0 G' OChapter 5      Engineering High-Affinity T Cell Receptor/ Cytokine Fusions for Therapeutic
* {/ `5 S/ c9 i% F3 X' ]Targeting    99 Jennifer D. Stone, Yiyuan Yin, Min Mo,- }- I6 w% F6 J# N! F
K. Scott Weber, David L. Donermeyer,- N  I. E* g7 t- v
Paul M. Allen, Roy A. Mariuzza and David M. Kranz
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! {( O, `3 E2 r9 R# ?7 [1 cChapter 6    Molecular Evolution Within! D) e& Y( x: Z. b
Protease Family C2, or Calpains    119( D3 R* q5 J+ V( Z
Liudmila Lysenko and Nina Nemova
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Chapter 7    FN3 Domain Engineering   145
; F" w/ c; r1 N2 Q! Z1 h1 CSteven Jacobs and Karyn O’Neil* \/ O+ W0 `% s0 g5 s, z, b0 \

% k1 h; ~7 D! d7 Z) i8 d! c# o5 j# |Chapter 8    Engineered Derivatives of2 v; x& ^% g. R" I1 p+ d# `
Maltose-Binding Protein   163
# g+ |; [7 {$ e5 @" d8 yPaul D. Riggs
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VI     Contents" H7 I4 O6 D8 v* B3 J

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( s1 e: o* b: S8 B4 X& `% jChapter 9      Applications of Bioinformatics and Experimental Methods  to Intrinsic Disorder-Based 1 W, C# E7 M* g( @0 [
Protein-Protein Interactions    181 Xiaolin Sun, William T. Jones and Vladimir N. Uversky
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Chapter 10     Protein Folding, Binding and Energy Landscape: A Synthesis   207" _% d) T* T1 S6 _5 N$ g8 t" j
Shu-Qun Liu, Yue-Hui Xie, Xing-Lai Ji, Yan Tao, De-Yong Tan, Ke-Qin Zhang and Yun-Xin Fu& Y8 r. ?3 ?2 Y
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Chapter 11    Protein Engineering with Non-Natural Amino Acids   253% i* _3 G! t5 K. F% r
Aijun Wang, Natalie Winblade Nairn, Marcello Marelli and Kenneth Grabstein# T, n& B: [/ x" ^9 A

# i+ x3 m" M# j2 |' U% p* EChapter 12    Generation of Xylose-Fermenting
( w* F9 {" ^+ N% A4 USaccharomyces Cerevisiae by Protein-Engineering    291
' ^) i5 [7 H) t) bSeiya Watanabe and Keisuke Makino1 F; e* q# P7 A' X! F4 W0 {
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Chapter 13   In Silico Engineering of Proteins
! |2 {8 X* L1 A1 c( n9 y- ~$ h' TThat Recognize Small Molecules    307 Sushil Kumar Mishra, Gabriel Demo, Jaroslav Koča and Michaela
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