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- 积分
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- 威望
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- 包包
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可是这个版本（如果是，我就给你下）：( p2 W: y. m& @/ h2 s' \/ m( t
Table of Contents
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I. Principles of Developmental Biology. W* K- l8 V1 y
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1. Developmental biology: The anatomical tradition
4 j" S3 k- |% P. t( v; O; s7 z& RNew techniques of mathematical modeling of development
( i. G/ b- y/ `' q+ i. e2. Life cycles and the evolution of developmental patterns2 ~4 A9 W- H2 r( I4 d. w; [
Recent advances in planarian regeneration3 u' ?) A& G7 h7 y* d4 J
3. Principles of experimental embryology% r5 x' a) h# V8 P; ?% `) F
4. The genetic core of development
, j2 i" v5 n* u) U( R& I5. The paradigm of differential gene expression
0 W n3 L( R4 i/ O2 b, sHistone modifications
! L: q# I; h7 S- W* c. WMicroRNAs
- Q+ D7 L5 z+ pPioneer transcription factors
5 S& |0 L* g4 |& I j2 b% ?Mammalian cloning and methylation patterns
# `5 y. e7 [& B, Q$ D" E: ~6. Cell–cell communication in development. d, e* p. ?8 J- H. H8 R2 w& n
Stem cell specification and stem cell niches
7 s- H1 i; ]. |0 ~8 c& x4 S; e; }; MMorphogenetic regulation by cadherins
) U4 C+ F: L( z( r& _: NNoncanonical Wnt pathways
. ?3 P" K/ @* U' H cDependence receptors and apoptosis9 v5 u* I6 v( A
Community effect and autocrine factors( g; c' ~7 l$ X
, A' X4 W. \% y' BII. Early Embryonic Development' t$ Q# X$ h8 M5 ~) ~
+ q, z N! ?; x8 c( I3 a8 V5 j
7. Fertilization: Beginning a new organism
* r. S+ {# y6 Y* k. X7 o) v5 m! zCortical granule components6 r; Q' {9 x% y5 U7 X3 C6 d
New mammalian sperm–egg binding model! J; E* }# b8 p1 m6 o' n
Mammalian sperm chemotaxis and thermotaxis
9 S1 e8 O7 m9 n# r VMechanisms of sea urchin sperm chemotaxis
" J1 i, ~ S R" C$ GSea urchin bindin receptor
- X, t& H( b# o' ?8 c( zOocyte translation inhibitors and their removal
" s! {- @4 g: ~! E" l) e* UNew hypotheses of sperm activation
/ r# e6 |: U: hMammalian sperm–egg fusion
0 U( }, C" X( d/ S7 D! `4 I) r D0 C8. Early development in selected invertebrates
+ W% I) @" o# h' N. J4 u/ N% @Wnt and Nodal in sea urchin axis specification" y! w8 }& l: \$ B
Coiling genetics of snail embryos! ~/ i9 ?( h" \: p W# a( I4 {% s
Functions of tunicate yellow crescent
- P- Z C2 S9 P5 e7 _5 g+ RRoles of FGFs in tunicate development
' h$ E3 o+ T+ h& q# v( t2 T# TTunicate heart development* d3 ~$ k G) a( j
9. The genetics of axis specification in Drosophila
s6 H1 i/ |2 L) uFGF signals and Drosophila mesoderm formation
. u1 a8 a1 A3 `5 c2 HTransport of Nanos and Bicoid messages to opposite ends of the fly oocyte& s" O8 Z X- C* U
New model for gap protein stabilization
* u. O0 s" e, E: F+ W7 X10. Early development and axis formation in amphibians. \4 F P6 {& w5 ^
New models for organizer formation in Xenopus
) I, `9 P* @* C, s+ UNew model for mesoderm specification in Xenopus
7 w/ n- D" }" Z& t5 y% [11. The early development of vertebrates: Fish, birds, and mammals
, {0 Q, l) \, n6 V2 F/ J# H9 NMaternal effect mutations in zebrafish
& }! {7 f# V( y& s; S6 rNeurulation in zebrafish
! j* Y" L# o4 ~& W' }& ~8 URetinoic acid in anterior–posterior axis specification in chordates
1 V i* Z x ?7 a* |Ciliary movements and left–right axis specification in vertebrates
j" ?) ~2 e, T% HRole of Cerberus in chick head formation* ?# o& o: P2 }7 C
Mesoderm specification and migration in chick gastrulae
) Y/ P: O3 }1 b2 ~# PFGF and cell fate in chick and mammalian epiblasts
7 r% y; k, q: t! g) lInduction of pluripotency in mammalian inner cell mass blastomeres6 W$ B' E2 W u8 g7 h. @, C
Homeotic transformation in mammals due to total Hox paralog knockouts
1 p* e5 u% a# b) B, |Controversy over blastocyst polarity in mammals
( ]5 F% f2 N3 _# a; `3 tFolate receptors and teratogens affecting neurulation" ^3 K6 K9 f1 C! ~6 i9 ~# S7 }5 x
# H0 K4 U4 h' {7 u) O
III. Later Embryonic Development
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12. The emergence of the ectoderm: Central nervous system and epidermis
' W& h8 I1 y5 _$ JGenes specifying neural fate* ?: ^6 Q$ g6 c" |! Q
Human-specific genes specifying brain growth
2 d4 L: o, [& q7 }7 i0 v4 e aProgressive myelination of the human brain) q d1 J- G5 k3 }
Neural stem cells
9 _$ e) T. h6 Q0 O7 ~/ dEye development and blind cave salamanders
' y+ a$ [; o GSkin, hair, and pigment stem cells( q: D" |0 \+ D/ Y* \$ O$ b
13. Neural crest cells and axonal specificity
( w2 Z. z% z ^6 qNeural crest cell specification and migrations% c2 j6 V U: j, i1 L
Head vs. trunk neural crest specification
# d/ f: Z) ^0 v [Neural crest-endoderm interactions forming facial structures
1 `+ z' G. B" c6 y. T6 s. w p: DPlacode specification and separation
5 a) o, E9 s0 v/ T3 `/ ?' O# h# z) {5 zTooth development and evolution) T) a! K4 S# i( v
Semaphorins, Robo, and ephrins in neural patterning& N& |7 \" z4 |9 @, j+ |" _
14. Paraxial and intermediate mesoderm
$ F2 ^* ]4 k' H+ LSpecification of paraxial and intermediate mesoderm0 B1 G6 q2 o( T% [9 ~. M* o4 H$ _
Epithelialization of somites
* i3 O1 b6 O# s4 ?# c% oThe syndetome—where tendons arise" e. B4 ~; i' h7 O! O
FGFs, Notch, and Wnt in somite specification and separation+ e+ R) x" \6 }0 C/ A4 N
The primaxial and abaxial musculature
9 J3 W$ `7 O8 g2 @9 i3 ONew sources of muscle precursor cells+ a/ |( q7 C: t7 I0 v6 [7 Q2 j8 _4 j
Pathways of skeleton formation
4 p: J! e z% O; s; qRegulating ureteric bud branching
5 B( U4 Y5 Z4 H3 cWnt and FGF proteins regulating nephron formation
# r1 r0 C& d( D) w" c* V3 |15. Lateral plate mesoderm and endoderm
- y& J- d+ w' z, \4 y3 o. aCloaca formation
) K5 k( Q, | D0 ^+ }Heart cell specification
: W# h2 |5 _7 J' f" y2 p0 fTbx genes, retinoic acid and heart chamber formation
( t6 B0 Z% |; k4 R1 t" |& _5 K4 D C. gHeart valve development
# }+ B8 S3 i2 C$ n1 y XHematopoietic stem cells and their derivatives
) C. e& j1 C2 Z+ e) V/ |Lymphatic development
( |6 E( X: g1 q' ]! I# OInduction of arteries by neurons
5 |; C9 K) f) m8 M2 _1 o! P+ mPlacenta as source of blood stem cells3 H3 a& I2 R- r; |1 H0 w
Adult blood stem cell niches" }2 E0 X# @- L/ {6 ?1 w0 J+ T
Endoderm specificity
7 @" b$ T0 h. d9 w) A5 |) JPancreas vs. liver development, f V- k$ A; q9 I4 r+ m
Fate mapping pancreatic cells
1 j5 d# u& Y1 g16. Development of the tetrapod limb& }7 }" h4 g' _3 \- x0 @
Hox code of limb development
) z+ r: K! z; B3 V1 ASpecification of the digits by hedgehog proteins and HoxD genes4 e1 |0 K; z0 ]) N5 Z
Controversy over digit identities in dinosaurs and birds
6 M- e2 k9 k3 _Getting limbs from fins
) k, l# h4 G( V17. Sex determination- ]7 y5 I& Y: s9 N& R/ ?& b
Timing and gene expression in mammalian sex determination
, f9 |, ~( Q( ^! `9 ?8 ]$ d6 wBrain sex determination pathways in vertebrates and flies
9 \4 Q# L1 q1 f& Y8 l8 K! zHormone disruptors and sex determination problems
6 u1 Q6 p: ~7 i8 J" m( |& G7 ^Dosage compensation and sex determination: _9 f+ H9 U* [' _+ E! w
Temperature-dependent sex determination in turtles" @, P% r/ @' A
18. Metamorphosis, regeneration, and aging
+ y: Q8 o9 d# t @Molecular mechanisms of amphibian metamorphosis* j2 A, g9 F/ j q. Z8 H# N
Ecdysone receptors and the response to molting hormone
% U/ e3 f& x6 o2 r: oCompartment formation in the wing imaginal disc
' ~+ s& p; s* o0 ]/ IWhy can’t we regenerate our limbs?3 d1 F9 s! M5 z4 y% E% d0 [4 O) v
Neuron- and mesenchyme-dependent stages of limb regeneration
% O7 {' r j, OSpecification of limb regions by transcription factors during regeneration
4 t# x% q- e; S3 [Mitochondrial control of aging# V K L/ C1 Q J; H
Insulin pathway control of aging and possible relation to oxygen radicals1 { ]/ Z( J1 s+ y! r& y: e
“Ageless” animals and environmental control of aging7 E3 s: @3 o6 A
19. The saga of the germ line& Y6 v4 T" W- K9 f
Genetic specification of germ-line cells in Drosophila and vertebrates6 [+ n" K. c4 V$ i. t5 E9 L7 W
Components of the Drosophila germ plasm
2 l, d0 x/ z9 I1 ]. g8 BEgg and sperm stem cell niches in Drosophila% `/ R3 `) d5 N/ {' m
Migration of primordial germ cells in mammals, chicks, and flies
5 G& ]- X2 ?) \( [9 k' fDetermination of meiosis and mitosis in C. elegans
. d4 C1 T5 D: m; ]$ C6 c( zRetaining mammalian spermatic stem cells# |1 P5 X3 ^2 m- x6 g
IV. Ramifications of Developmental Biology
- ?' S* q5 P% d5 y4 w4 j20. An overview of plant development+ ]) B% f& Y x+ b
Gamete formation and pollen tube guidance
7 Y1 {9 E7 a8 s5 R) i' OMaternal effects and embryo development }- c5 C: R4 G1 `; d0 V1 ^) j
Radial and axial patterning+ j6 ?$ y5 }4 D. {4 H
New model for auxin specification of polarity3 y' C: B; t) L( F
Roles of microRNAs in plant development
1 j1 w+ X, w: C* Q6 M+ rDorsal–ventral leaf patterning
( f0 E2 w0 X- S/ D% p. W$ L }Long-distance RNA transport and flowering
% j8 F5 j" D/ h, D1 B8 _Floral meristem specification4 f, C) [, \- }
21. Medical implications of developmental biology& s v. o8 c( U' W' C+ j
Mechanisms of alcohol teratogenesis
- S* u8 l& R1 d: a5 eEffects of endocrine disruptors on human development
! V. Z: Z: o: h# V% nNutritional effects of gene methylation and disease susceptibility
8 x& N4 K4 P' hCancer as a disease of development
7 F( O* K1 J$ D7 e& j% V" t( K. ICancer stem cell hypothesis* T4 B% `0 c# y. q: ~0 p- ?
Developmental approaches to cancer therapy
9 U$ F9 \: q; z2 ]: z. C3 V" bStem cell therapeutics& ?- a: k" Y& \4 r0 d
Regenerating human limbs and neurons
& |3 @8 l4 A$ z# j c2 N0 a! `22. Environmental regulation of animal development
9 ^' Z1 a. e/ W( m, NMolecular bases for environmental regulation of gene expression
$ w D& h5 X! b0 l2 X2 ]; f• Importance of symbionts in mammalian gut and immune system) V" N: A) ]0 E' |' O
development
- ^- {1 X+ n' M' ]+ n4 QSignaling from fetal mammalian lung to initiate labor" L) S" g* L2 t3 T' A/ N
The role of nutrition in the development of the dung beetle/ j7 @" I) t8 X( y3 l
Predator-induced polyphenism and toxicity testing
/ z0 C2 Q( p4 n } f% w. @7 A4 {Genetic assimilation of environmentally induced traits
, |. {1 z0 q! O8 r23. Developmental mechanisms of evolutionary change
+ Y. w3 E+ ~# eDevelopmental modularity and evolution (stickleback studies), |7 S9 X9 R" J
Evolution by heterochrony, heterotopy, heterometry, heterotypy
- ?# {+ a! H1 bBMPs and Darwin’s finches
# o) ]) j3 G9 b9 |1 SOrigin of neural crest cells and the origin of jaws5 ~: U" z2 H: a7 R; N9 o, I
The search for the Urbilaterian ancestor |
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发表于 2009-9-25 02:27
发表于 2009-11-19 00:18
