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本帖最后由 kephort 于 2010-5-27 12:41 编辑 ; `: n ]3 e$ v$ e8 s
8 T0 e$ f0 j+ c0 k& l2、polycomb 和 trithorax(protein)在干细胞的分化及分化中的多种表观遗传修饰发挥着重要调控作用,下面是这些基因和调控信号通路相关的重要文献:9 ?" R* e( Z: X {) f6 f
1. Simon, J.A. and R.E. Kingston, Mechanisms of Polycomb gene silencing: knowns and unknowns. Nature Reviews Molecular Cell Biology, 2009. 10(10): p. 697-708.6 ]( m( q" A) y
2. Schuettengruber, B. and G. Cavalli, Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice. Development, 2009. 136(21): p. 3531-3542.
5 E& ^9 l) o. A) A; t9 D3 M3. Kerppola, T.K., Polycomb group complexes - many combinations, many functions. Trends in Cell Biology, 2009. 19(12): p. 692-704.
- N% ^1 p3 I; \3 O0 l' ]+ W4. Schwartz, Y.B. and V. Pirrotta, Polycomb silencing mechanisms and the management of genomic programmes. Nature Reviews Genetics, 2007. 8(1): p. 9-22.) A1 [2 C6 l2 {% F7 I9 I
5. Schuettengruber, B., et al., Genome regulation by polycomb and trithorax proteins. Cell, 2007. 128(4): p. 735-745.
# l# i4 @% \7 b* b$ C( ~6. Sparmann, A. and M. van Lohuizen, Polycomb silencers control cell fate, development and cancer. Nature Reviews Cancer, 2006. 6(11): p. 846-856.$ y5 Y) ^) s& s+ h* ]' J3 g
7. Muller, J. and J.A. Kassis, Polycomb response elements and targeting of Polycomb group proteins in Drosophila. Current Opinion in Genetics & Development, 2006. 16(5): p. 476-484.' {/ g: n2 a; r; i; ~' ~7 q
8. Bracken, A.P., et al., Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes & Development, 2006. 20(9): p. 1123-1136.. N. C$ ^9 u" |+ T6 y7 v# Z
9. Boyer, L.A., et al., Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature, 2006. 441(7091): p. 349-353.8 K& H p( @6 a4 g0 A# F# j
10. Bantignies, F. and G. Cavalli, Cellular memory and dynamic regulation of polycomb group proteins. Current Opinion in Cell Biology, 2006. 18(3): p. 275-283.
! _' l! N' k- j( B11. Levine, S.S., I.F.G. King, and R.E. Kingston, Division of labor in Polycomb group repression. Trends in Biochemical Sciences, 2004. 29(9): p. 478-485.
) S0 K! m% \1 e12. Lessard, J. and G. Sauvageau, Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis. Experimental Hematology, 2003. 31(7): p. 567-585./ a6 y$ E+ d# h1 [# Z) I$ t* W
13. Simon, J.A. and J.W. Tamkun, Programming off and on states in chromatin: mechanisms of Polycomb and trithorax group complexes. Current Opinion in Genetics & Development, 2002. 12(2): p. 210-218.
9 }6 v4 b, f8 h14. Schumacher, A. and T. Magnuson, Murine Polycomb- and trithorax-group genes regulate homeotic pathways and beyond. Trends in Genetics, 1997. 13(5): p. 167-170.: ` E0 d- a6 K7 S8 u. ?
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