干细胞移植用于肝再生治疗的相关研究进展

guokeyi

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8 J+ p! f5 Q5 b, _3 O6 T刘晓珑　李波
2 q4 S- V4 a: ?8 O* y( p+ f　　【摘　要】　　目的　对干细胞移植应用于肝再生治疗的相关研究进展进行综述。　方法　广泛查阅近年的相关文
) A* f# v% K5 A0 W$ @献, 对移植研究中常见的干细胞类别、修复机制、植入途径以及临床相关问题进行综述。　结果　修复肝脏的干细胞可以
" ^! D) X* p: g* t2 D分为肝源性干细胞和非肝源性干细胞; 修复机制主要是融合或转分化; 植入途径以门脉内植入多见。目前仍有许多临床9 @  y: S* O& }. a# Y
相关问题限制干细胞移植的应用。　结论　提高干细胞的临床实用性需要更深入的研究。
( f2 t+ F( C' {& E) z( m" o  P7 @, k【关键词】　　干细胞　　再生医学　　肝脏2 `: I9 G8 ^5 ]% V
中图分类号: Q 813　R65713　　文献标识码:A
2 q% _, B7 w9 ^  }2 O. hDEVELOPMENTOF L IVER STEM CELL TRANSPLANTATION FOR L IVER REGENERATIVE TREATMENTöL IU
' c9 V. S  u( xX iaolong , L I B o. D ep artm ent of General S u rg ery , W est Ch ina H osp ital, S ichuan U niversity , Cheng d u S ichuan,
: ]3 ~( q3 A9 E, a1 ~610041, P. R. Ch ina. E 2m ail: g x lliu@126. com
5 Y4 H; u0 F, p2 eCorresp ond ing au thor: L I B o, E 2m ail: cd libo@m edm ail. com. cn& H4 j/ p8 j5 R# L+ D1 h  X
【Abstract】　　Objective　To review the development of the liver stem cell t ransp lant fo r the liver regenerat ive4 |: Y, V& ?$ J
t reatment. 　Methods　The t ransp lantat ion2related art icles about the stem cell classificat ion, repairing mechanism s,6 }( n+ |0 k, C7 G* x- t  f
adm inist rat ion routes, and exist ing p roblem s in the liver regenerat ive therap ies repo rted in the latest literature w ere1 @: L3 r1 E$ t% r, o/ ?
extensively review ed. 　Results　The related liver2repairing stem cells w ere found to be inside and outside the liver,* C& S8 N4 {  D6 P- O' S
i. e. , the hepat ic stem cells and the non2hepat ic stem cells. They could repair the liver by the mechanism of the cell
' I. ^* s9 ]' n6 S$ H" _: D4 b; H2 x3 cfusion o r the cell t ransdifferent iat ion. The stem cells could be adm inist rated via the po rtal vein. How ever, the
# q$ c  Z1 T7 N8 p1 a! ^, rapp licat ion of the liver stem cell t ransp lant w as rest ricted by many related clinical p roblem s. 　Conclus ion 　Further" G8 P% q) Y! _" ~
studies are st ill needed fo r an imp rovement of the clinical feasibility fo r the stem cell t ransp lantat ion, especially fo r the
* W5 R' M$ u+ ^liver stem cell t ransp lantat ion.
; P' {6 Z0 n2 ?/ ^【Key words】　　Stem cell　　Regenerat ive medicine　　L iver9 `& J! p/ J- v& B" {1 k
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