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& E F G( l& K0 w6 sVolume 20, Issue 10
/ Y' @! p4 P4 ]3 z! y$ aOn the cover: Smad transcription factors are central mediators of the effects of TGF-β (transforming growth factor-beta) and BMP (bone morphogenetic protein) on numerous aspects of metazoan development and tissue homeostasis. The TGF-β pathway is tightly regulated, including a feedback process in which two sets of Smads play complementary roles in the signaling cascade, as they can either inhibit (Smad7) or activate gene transcription (Smad1). Aragón et al. (pp. 1726–1736) provide a structural basis for how regulators that use WW domain pairs for selective interactions with phosphorylated R-Smads resort to a single WW domain for binding Smad7 to centralize regulation in the TGF-β and BMP pathways. The cover uses the analogy of a chemist's shop equipped with jars storing some of the proteins participating in TGF signaling. The feedback process is represented as a balance loaded with YAP bound to Smad1 (on the right) and to Smad7 (on the left). Cover image designed by P. Martin-Malpartida (PMM) and M.J. Macias and created by PMM.: V- W0 W( a8 b! e4 D; ]% e" ^& L
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发表于 2012-10-14 11:37
