Epigenetic protocols

pujixing

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& R  }9 e8 C: g! |The scope of epigenetics is vast, and an exhaustive analysis of all of the6 @! T' ~+ `3 a/ U. A* j
techniques employed by investigators would be unrealistic. However, this2 p! e0 K. P( m( ?
volume of Methods in Molecular Biology™ covers three main areas that should9 B8 M% V( X" U; O4 m6 }; M
be of greatest interest to epigenetics investigators: (1) techniques related to: E7 N1 p9 P' s' U5 e7 l7 ]0 ]# B7 |
analysis of chromatin remodeling, such as histone acetylation and methylation;
+ i) W2 Y4 S' b- k(2) methods in newly developed and especially promising areas of epigenetics: F' B. _$ V. C& A
such as telomere position effects, quantitative epigenetics, and ADP6 D1 f6 c9 B' S+ q4 x
ribosylation; and (3) an updated analysis of techniques involving DNA
& b. Z0 H- E9 o3 F: mmethylation and its role in the modification, as well as the maintenance, of
' U/ ~. J! @6 T/ `9 c% lchromatin structure.
. {0 N! \. N9 O$ KThe protocols presented in Epigenetics Protocols are intended to provide
7 I5 h+ k$ O# M3 Zinvestigators with a contemporary set of tools that can be applied to research in' S/ n* e1 I# a* e+ Y. i* |
the field. These tools include recent breakthroughs in epigenetic analysis such- S- F, `+ M; G$ e9 N; h
as techniques for determining changes in native chromatin, methods of
8 B$ A, @4 f& F: \$ Dmicroarray analysis as applied to epigenetics, and methylation-sensitive singlestrand
6 q/ {+ N! o: U$ w& E* Wconformation techniques. These methods, as well as many others, D( V& M- a; Z4 j! N, c( |
provided in Epigenetics Protocols, have strong potential for further facilitating1 J% Y* Y% j1 B& m/ X/ q
developments in this promising and rapidly developing field.
* X/ A) y" B4 j$ {- B4 U) NTrygve O. Tollefsbol

sunyucheng

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基拉

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KMA

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wujunyu

谢谢LZ，先瞅瞅

淡定

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