- 积分
- 881
- 威望
- 881
- 包包
- 5504
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1、There is considerable evidence that several diverse cancers, both leukae-
! q, l/ |8 I9 n5 dmias and solid tumours, are hierarchically organized and sustained
. H W" p- A7 o k- @1 kby a subpopulation of self-renewing cells that can generate the full
# S! e) g4 f- _repertoire of tumour cells (both tumorigenic and non-tumorigenic
* A7 d' P* L9 Y$ b. K! P# U1 Ncells)5 L: b) E6 i8 o" x
2、expression profiles、intertumoral heterogeneity、 oncogene addiction、
! _) I6 y; P5 Z# d1 W# Qsurvival roles、 committed progenitor cells是什么意思?
0 p' j1 F, M7 _3、Interestingly, despite ' Y& u9 Q, I2 f1 B4 {$ G, q
the heterogeneous nature of tumours, the histopathology and gene-& U7 `0 y, p5 U0 { s' z4 e- \
expression profiles of tumours arising in patients often remain relatively ! Z0 i6 j# b, T
stable during progression from localized disease to metastatic and even / w7 o5 z) I. M \4 \' I6 {
end-stage disease3
; ~. v2 c3 X* D* Q$ o4、transgenic mouse models have shown 1 {1 v+ y% q8 R! x2 h+ i
that mutant Hras targeted to the hair follicle region highly predisposed
$ `# L" W" d/ Y& R# \mice to squamous carcinomas, whereas its targeting to more differ-
. @7 E1 K u, P4 e# V9 Tentiated interfollicular or suprabasal cells resulted in papillomas with
+ m: n% t( P8 k5 C5 _* ~low malignant potential。Moreover, transformation of distinct breast 5 F( Y) p- g T Z& Z( x
epithelial cells in vitro has indicated that the target cell is an important
' ^% C5 s# _9 x! Hdeterminant of tumour phenotype
/ _- K; N3 L z" `5、Nevertheless,
8 a9 X% u q% V Tany cell in the hierarchy with proliferative capacity could serve as a cell
- D: X/ k( i2 w1 g) bof origin in cancer, if it acquires mutations that re-instigate self-renewal
F* H* f7 M% Icapacity and prevent differentiation to a post-mitotic state- V/ s9 W1 w5 p1 Z" i3 e3 q
有点多哈~~非常非常感谢~有些感觉上下读起来根本不连贯。云云雾雾的! |
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