microRNA与干细胞

细胞海洋

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，microRNA在干细胞的自我复制、定向分化和组织再生中，都起着十分重要的作用。它是干细胞特性、维持、转化功能的一个关键的调节者，是当前干细胞调节研究的一个重点。最近，Gangara Ju. VK和Lin H在Nature Stem Cell作了一篇综述，系统的总结了microRNA对干细胞调节作用
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" V. _9 ^8 p, j: C但是，microRNA对干细胞的调节作用还远远不止于此。它还参与细胞周期、细胞重建(Reprograming)、多能干细胞生成、信号传递、特异分化、Riches、修复、再生、变异、代谢等所有过程

maxiaorongqp

有这部综述的全文吗

细胞海洋

MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1
; r' J) N" p0 H1 A7 g$ JMicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells
$ ^+ m% c, `% g, W0 m0 jMicroRNA Regulation of Stem Cell Fate ' t- [% n, H* x. f& j+ {
MicroRNA-145 Regulates OCT4, SOX2, and KLF4 and Represses Pluripotency in Human Embryonic Stem Cells
, ^3 p, ]! Q7 ]- K$ t: x* VMicroRNA-145 to control human embryonic stem cell (hESC) pluripotency and differentiation
6 Q4 B& ?% U! Q% b5 R* p7 CA feedback regulatory loop involving microRNA-9 and nuclear receptor TLX in neural stem cell fate determination & |- y3 l& U+ ~: Q$ ~/ m
An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network
' U+ w2 Y3 o0 u/ X, r3 Cca-let-7 microRNAs in development, stem cells and cancer ( T7 ]- r; t4 _/ F
Ca-Metastasis-from dissemination to organ-specific colonization
! A1 @' h/ m, X( c/ l) E  i' ~2 L! PCell Cycle Regulation by MicroRNAs in Embryonic Stem Cells
$ B$ j/ R$ A+ T  GChromosome instability is common in human cleavage-stage embryos , I/ ]* Y& e. r7 {
Comprehensive MicroRNA Profiling Reveals a Unique Human Embryonic Stem Cell 2 H% R. K# {. Z4 {
Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells & L  c  d7 w. k# `/ E+ r+ [
Differentiating human multipotent mesenchymal stromal cells regulate microRNAs   A9 B/ S& w, R& V# ^
Embryonic stem cell–specific microRNAs regulate the G1-S transition and promote rapid proliferation 4 n+ j7 J1 H6 x
HMGA2, MicroRNAs, and Stem Cell Aging   k, {. I/ s' \$ N. Y
Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing 0 X# U7 i8 e0 `6 m
Lin28 Mediates the Terminal Uridylation of let-7 Precursor MicroRNA
6 b9 ~. w% J' N% }) Q% m+ O; kLong noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation
- Z$ t/ P$ o) G9 j* iMicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells # R" J0 Y2 K. M5 s! ]) t
miR-145 in Stem Cell Differentiation
8 `( d! F2 T4 yMIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells 8 l* R3 F# a( w6 f- F* v
miR-9 and TLX-chasing tails in neural stem cells - G( k/ \/ V% {( g
Multipotent adult germline stem cells and embryonic stem cells have similar microRNA profiles
) u3 H6 n; c6 U3 e2 cPluripotent stem cell lines 8 n, g& C1 ^. U7 i1 H% `3 {* \0 G
Regulatory circuits underlying pluripotency and reprogramming
" j' [3 D3 e6 h( @sc-MicroRNAs to , and coding regions modulate embryonic stem cell differentiation
4 k' y7 p+ f7 a4 ], O9 |  ^sc-MicroRNAs-key regulators of stem cells 1 W7 _# v( V) R2 ^! G- F/ d  U
MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells / B7 t5 C" q; W& i0 Q( F
Stem cells-MicroRNAs promote differentiation
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# S1 B# Z4 t: MStem cells- MicroRNAs promote differentiation
+ Y( m+ [. y5 z2 I5 x4 S* FMicroRNA regulation directs lineage-and developmental stage-specific transgene expression in hematopoietic stem cell progeny

guanjiyu

谢谢分享

fuguangbo

好文章！谢谢！

sacia

好东西~楼主辛苦了！！

ouyi2738

Embryonic stem cell–specific microRNAs promote induced pluripotency

sdyinong

谢谢

yaner

有全文吗

Rainnie

microRNA，包括miRNA、SiRNA和PiRNA等等。它们是基因表达、修饰、转录和翻译的调节者。近年来的研究证明，m ...  L: ]! a/ k" K
细胞海洋 发表于 2009-10-29 18:58

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   全文有么？