本帖最后由 细胞海洋 于 2010-5-21 06:54 编辑 / ^3 [! U. q7 ^& y, p% P" H" V5 u1 }+ q: F: s7 @* J1 R8 T
李凌松*，王 莉" d1 {% J8 i- M0 O; Y" b- I: [
（北京大学干细胞研究中心细胞生物学系，北京 100871）) ]: M8 I+ m: w: g! Z( a
摘 要：胚胎干细胞具有自我复制并分化为人体各种功能细胞的潜能。胚胎干细胞具有的独特生物学 9 E2 k, \' s2 I& p6 o0 {! g6 ^特性使其被广泛应用于生物学研究的各个领域，特别是发育学。同时，它潜在的医学应用也成为世界 5 j. N: [$ Y7 L/ `. R范围内的研究热点。但是，由于人胚胎干细胞的来源为植入前的早期胚胎，人胚胎干细胞自诞生之日 . y; q$ B7 J) q! v. ?$ i起便倍受争议。本文将从胚胎干细胞的来源、特性、鉴定标准、增殖机理、应用前景以及研究本身) A! p; F$ ?+ o- w9 r, w
涉及的伦理学争论给予概述。1 Y M6 O( _* j7 Y Q
关键词：胚胎干细胞；自我更新；分化；鉴定；胚胎生殖细胞；应用9 T" _2 X) \* O
中图分类号：Q813 文献标识码：A ) _( x6 s. l' r$ @: K8 k% C$ S! REmbryonic stem cells 8 }, u% I! ^( s( E' ^/ ]LI Ling-Song*, WANG Li % R7 H0 X& ]/ U(Department of Cell Biology, Stem Cell Research Center, Peking University, Beijing 100871) / P2 Z+ z# G. M1 ~3 x) H+ ~, tAbstract: Embryonic stem (ES) cells are able to self-renew and differentiate into all kinds of human cells. Due to $ V& W" U. L' G9 _+ @. V/ H8 y8 ytheir unique properties, ES cells are used in diverse fields of biological research，particular in developmental# O* V4 a& a$ o! T) W
biology. Meanwhile, their potential medical application become a research hot-spot worldwidly. Since preimplantation- g( p6 b2 ~! N2 [3 S) G
eggs are sources to generate ES cells, the use of embryonic stem cells is therefore controversial. % U6 B' s) ~6 X3 M& `# Q; ?4 sThis review will outline characterization of ES cells, regulation of self-renewal, and the applications of the cell 6 M& k! B: U0 R# yin treating diseases, as well as ethical issues related to human ES cells research. % V, p0 N& Y; h8 u6 ^Key words: embryonic stem cells; self-renewal; differentiation; characterization; embryonic germ cells; / y% a: Z& g* ~. _3 P) C. Y# ]9 V6 U3 m, ~) P
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[attach]136[/attach]作者: liyaodong 时间: 2009-6-24 18:48
