脐带间充质细胞免疫调节

luyue6453

最近在论文中看到下面一段话，不能理解，为什么间充质细胞具有免疫抑制能力就会对受损神经的修复有好处， 求解答。) ^2 w/ [9 x: m7 E* r0 r! S8 z9 O
Recent studies have suggested that the immunomodulatory activity of MSCs is of crucial 1 ]  ^4 T2 m! s; P" F0 C
importance to cell therapy using MSCs. There is in vitroevidence that MSCs can directly modulate the function of T-cells. Moreover, they inhibit the maturation and migration of various antigen-presenting cells, suppress B-cell activation, induce suppressor T-cell formation, and alter the expression of several receptors necessary for antigen capture and processing
. v. b4 l* A0 R& S4 B& p; u; s. This immunosuppressive activity of MSCs may play an important role in the repair of nervous system injuries.

jxydiandian

可能是神经受损后，机体会产生过度的应激反应，产生过度的免疫调节机制，将受损的神经当做异物，从而使受损神经无法修复，而MSC一方面调节机体的免疫机制，一方面通过分泌促进神经修复的各类因子或直接取代受损细胞的方式，多种途径结合从而修复神经，这只是我个人的理解，抛砖引玉，希望专业人员解答，谢谢

ccwei0615

Could you provide the information after this sentence? I think the author should mention something concerning the point. BTW, jxydiandian's comment might also play an key role to prevent immunoloical attacks after the nervous injury. But I son't know how to have a function on repair.  

zjj196512

mscs may increse some cotekines that have trophic effecton to nerve.

lordstar

实际上干细胞对神经细胞的保护有两个方面，一个是immunomodulatory作用，因为大家知道细胞损伤，尤其是体内的神经细胞损伤很大程度是炎性损伤，inflammatory damage，而炎性损伤的上游往往是杀伤、辅助T细胞等通过过度的炎性因子实现，而干细胞的免疫调节作用可以减少th1增加TH2、treg等极化，故可减轻损伤；另一方面就是trophic 和tissue repair 的作用，比如营养性的旁分泌作用一些growth factor，对周围循环的改善VEGF等