老狼的个人空间记录

sunsong7

"genetic mutation" should be exactly as "gene self-editing"
3 M& `. P5 }& h7 f: |2017-12-1 13:171 b" E2 w. l0 @3 }# W
Bioreactor in vivo would be the terminator of illness.  e3 W4 w1 a2 T: |3 n5 q, L
2017-11-20 23:09# E0 x  o5 f0 e
renew tech：剔除衰老（病变）细胞占位可以恢复青春。  n) X4 S. q+ ^9 I! q
2017-10-23 12:50/ ]$ |, c5 o9 _7 g! G5 P0 F
魔不疯，鬼不魅； 道非盗，仙非妖；神无形，兽无极。) U( U3 K1 q8 O( o6 ~; X
2017-9-30 10:583 S# ]5 Z6 B0 n8 B% n, z
Life 3.0——from decoding and coding to reading and writing. @( o& v: {. o& g
2017-9-21 22:32
$ j7 W0 x9 P+ f* {, P理论创新：亮明立场——先颠覆，再完善
. W( ^4 _8 d* }: N; P/ S2017-2-7 00:07) H( T8 ?4 \& |4 T
干细胞第二定律：与细胞外基质共同构成多潜能；
5 R$ b5 y0 Z# x$ m$ {2017-1-3 11:14
8 z! Z5 j2 C# \, l3 y4 L干细胞第一定律：全生命周期保持增殖分化能力；
! ]/ k0 }7 g8 Y+ w$ O' n  I. E2017-1-3 11:13
) R2 Y% V7 L  M/ tNgAgo——Never give A guideline operated！
* P8 [, T, c6 @( K2016-12-1 10:09
  ~6 \& Y4 C% q( m6 t表观遗传—— 一切皆可改变  一切皆有可能; b6 [! a" v, g9 A5 h8 `
2016-8-17 23:379 {0 |! X0 Z0 z. |0 k
子曰：吸血鬼疗法——养儿防病 养孙防老
) d& B4 w% t. P! R: H2016-5-23 12:05
: W9 ]$ G8 f* h8 f8 {2 INgAgo——Debug tool kit for mammal cells
0 f; ]$ v, K4 ]% I8 O1 m9 ~2016-5-9 13:091 W' L4 ]% U! x( v8 I; u
公理之外 皆需证明； 科学命题 皆可证伪。, k# ~0 B2 t2 S: l6 }0 o
2016-1-2 00:20
& G# {0 R% B# A: V* V低氧——破坏线粒体功能、诱发炎症、导致基因突变# i- }" l+ J  M5 g
2015-12-16 20:19
) q- s( @9 E( F9 m6 A$ _- x1 P- Z4 l9 {癌症——炎症部位组织再生过程中细胞去分化失控形成的幼稚化新生物。2 C4 t; t8 o6 R9 @! K
hcoohboy: 一个有趣的假设~但是没有炎症就一定没有癌症吗？ (12-18 16:16)9 p* v4 Q7 K( H5 m7 b& [% ]
sunsong7: 炎症与癌症同在，Hanahan D, Weinberg R A. Hallmarks of cancer: the next generation[J]. cell, 2011, 144(5): 646-674. (12-19 19:45)% B  v3 O; r' F6 g
hcoohboy: 3ks~ (12-24 16:45)2 Q& F* v) k3 z6 U0 v1 z$ v+ f( \
2015-11-18 15:54, a- c& X  l1 K* T0 R
抽象世界与客观世界的真理判别标准是不同的： 在虚拟数学世界里，逻辑是一切命题的唯一审判标准； 在客观物质世界里，证伪是一切定律的最终审判依据。- i+ o8 X! g& Q2 z/ k! K
2015-5-20 14:13
6 P! u$ ~+ k! b# Z 传统生物学将死：进化论=自然神论   基因轮=宿命论   细胞论=活力论翻版。    现代生物学曙光乍现：系统生物学=数学 结构生物学=物理学 合成生物学=工程学7 O. T5 t" d- y' M4 ?
helong: 系统生物学是把细胞、基因、进化、物理学、信息学（数学）、工程学等都打包起来的所谓新学科，目前只做到了简单组合，还没有达到系统集成阶段。合成学更多偏向于化学。 (4-21 19:28)
& c; ]) W2 y0 R3 o- S4 `8 ssunsong7: 方向对头，努力总会有结果的 (4-21 20:05)1 r/ w& d4 s3 a4 i
2015-4-21 16:46
% a* B6 A/ S  [. n2 d8 Z+ bsearch and research is just disassembling the creature.
1 R% R) G7 P" c! z2015-4-7 17:01
, b* B" J9 @1 u; \* D: [* gselection is  the act of intelligence) @* h' C/ x7 X. F: y
2015-4-7 13:49& S  U$ P; ?# N, `! m
Genome fusion create neoplasm/ Z0 ~1 m0 [" _) e- ?* F+ b2 V1 d- d
2015-1-20 13:106 |7 k$ E0 q$ r# F, c; s
STAP——Stupid Trick  Against Professional 5 J+ O& O  T+ Y" @4 E
2015-1-1 19:29( i* N5 }, h1 |5 L" v/ l4 l/ P
information=structure=negentropy- a5 P2 y8 r% T
2014-7-22 17:367 T& _9 V7 T2 e
Natural mutation does not result in new functional genes 
* U7 t/ a% e& t. r' n2014-7-3 14:06# e/ G$ F3 \- Y9 W3 |4 c3 E
life is wisdom creation instead of natural evolution
" H1 _8 ^( Y0 ^5 ^# k2014-3-27 09:33/ b( H( ?& x' S; Q% s) A$ g
let us explore the source code of life !$ H* ]& z# y. q; ~0 u7 T1 t% T
2014-3-11 13:11
+ F+ \9 B* x) q; z4 w  |1 ]9 Lbio-manufacturing——processing，machining，casting，printing，3D prototyping，duplicating，cloning，life replicating.* T, D. O5 ^6 R( Z/ i" R* R
2013-10-7 23:06+ }* Y: V  K1 d6 Y
induced abortion would give the key for curing cancer 2 T" {- c3 e- L0 i. A1 h
2013-10-2 23:33" w+ w+ J/ L, L) t% ~; N
“key breakthrough” in molecular biology are entertainments& S. p, v# G& J2 l: `  P$ T2 i
2013-6-16 11:50! k% i7 }; d3 f2 }3 _- A
Rules Of Living：trial-and-error exploring，survival takes the legitimacy
5 f9 b; ^% x! l2 y5 M2013-6-16 11:27
0 Y  c. }5 Q3 Q' rLife is a set of debuging programs
1 d8 ^( ~6 I% P* r2 S2013-6-15 18:402 ^$ ^6 x( i  i9 q
current biology is closed，destined and agnostic，it is  the only contribution is to kill cells; d& n/ O: D: a* a9 W
2013-5-2 08:54) w$ i" @/ ?0 w1 R9 b8 D
information，energy and construction are the new base stone of biology，instead of evolution，gene and  cell  tales
3 t, J) w2 l* A7 W- V3 \: r2013-5-2 00:51
7 g. p5 k' R" M4 N  S# F! ]virus is the messager of  the universal life network
8 Z6 p/ ^, o' N: P( Z/ h/ k2013-4-18 14:33* g9 `' a& _8 r" T
Genetic information doesn't improve cancer risk prediction" W5 ~2 Y; E7 d& z% V2 B/ U
2013-4-1 09:20- i( d9 y# |: ^7 \0 t
There is no early diagnosis of cancer，but early prevention of it
0 Z4 ]% j6 [5 a- ~2013-3-27 09:172 Q) z& A) t. w5 x" u
hypoxia maintains stemness or carcinogenicity
! L8 H& p4 ]9 \; J, ]2013-1-2 05:21
, H. j! j+ o$ R. b5 Wcancer is the living fossil records on origin and evolution of human being7 [* h8 Z5 \7 i2 L! v0 u# i
2012-12-9 23:31
0 q6 \' V& m* ^: Rinformation island results cancer
) D) X9 Q! Z0 T/ K0 D) v+ |2012-12-9 05:23; p: I  S7 \. [
life is digital game. \. n3 F0 I. ]  ]
2012-11-10 00:17: j' U* l2 F3 Z* A. b$ s
cancer ——severe abstinence reaction of cells to niche addiction
) v6 i' w+ x+ q5 v8 y. J% ]1 L2012-9-28 12:11
, v. W( B6 Y9 S* R+ @- l( c未来生物学终将回归物理(熵)及数学(分形)的美感  o8 ?4 l! M4 r; S( J; T9 N
biomater: 熵理论适用于任务物质。。。。也适合于生命 (9-26 09:28)& u4 H( I; P- h3 D4 }: G9 N
2012-9-25 21:22
, T$ p9 v" w. ?/ j& p# ^3 }% m9 Omembrane holds the key to life  N  X9 q3 V2 g0 |7 h6 V2 ~
2012-8-19 20:24/ N' v7 k. }) t: Z8 `- f9 x: R* F
Cancer is the default state of cells+ D2 |* u; ^7 L2 ]& V4 a) V
2012-6-26 22:17
, _; d2 ^3 T6 ^! j1 [1 [& ^% r4 @mainstream cancer theories could be overthrown！+ E9 P) l5 }1 L/ j* q' W3 i
2012-6-25 15:43
3 @1 C4 S- Z9 f1 Tcarcinogenesis has nothing to do with the gene mutations but is  the result of niche reprogramming.... v9 u9 B* N: q7 k+ I; F5 C$ n
2012-6-7 09:36
+ Q% {+ B& m& G/ m) G" k! Zevery living organism connected with the water， one cell one world- g3 i# W- e+ F" w) }/ k& `5 b5 \- W
2012-4-19 22:063 @. @3 l# L  u' X7 }/ N3 Q! `
chemical structure of cancer cell determines it's biological function...
& O, o& D1 O4 h2 |  r) A/ M6 M2012-4-7 17:562 N$ t- m; C/ u7 Q5 r9 z
Mann tracht und Gott lacht
2 {4 x1 k1 w$ b6 x6 x2012-3-24 21:34
8 k) w9 i: d: K2 O  rDarwinism or genetic determinism is a fairy tale！5 U1 {  F4 ^, I/ J! [$ M
2012-3-13 15:18
* o' z" ^; g  d7 Aniche isolation is essential for cancer speciation$ W# Y1 F$ n/ K: f7 T; A
2012-3-12 12:07
) x* L! O$ W4 Z7 XHybridization Creates New Species，Mutation results species extinction
: A9 N; I5 I- ~+ |& X2012-3-11 18:21
: n  [. V( @8 e0 WROCK may join the niche reprogramming...
* U  g% {# a. `yuhaoze: 这是篇文献吗？ (3-9 10:41)2 n, n: R9 M  R. U" E+ b# t
sunsong7: http://www.stemcell8.cn/home-space-uid-6268-do-blog-id-1211.html 突破：病人体细胞及肿瘤细胞长期体外培养（附原文） http://www.stemcell8.cn/thread-51419-1-1.html (3-9 10:46)
5 E. a! j$ A; [! `9 k/ q: m9 iyuhaoze: 啊， 我看过这篇，还顶了呢，谢谢哈 (3-9 14:37)
3 y; R8 ]' b2 I8 V% ?" t6 ~3 E2012-1-19 10:52# z9 N/ S: G! O
oncogenes are pseudoscience1 ]1 L' E# G8 L
2011-12-29 13:55! M) m& }0 |/ m7 d( D% l
gene mutation leads to variation or extinction, not new species
" X  z, b. j# n  G$ `' S+ J2011-12-29 13:28% C1 }' h, j1 }$ F$ N
oncogenesis is non-Darwinian event
/ W8 H, s! w6 F# ^4 Q# R0 z! S$ i2011-12-28 22:56% m& @8 \" G, I+ V
disorganization activate neurogenesis activate oncogenesis   
5 ?7 R4 `& c- M& j' H2011-12-22 23:38
0 l' _" l3 b6 D( l4 zMSC is cell feeder，tissue scaffold，immune firewall and biological glue6 |5 W( ^8 t1 ~: d  L0 k
2011-12-19 19:46
: ?* f) A8 q6 L+ t' C9 Kcancer is Noah's Ark（species carrier and life explorer）
$ `$ h$ G  P7 h" P/ W% z$ i' d2011-12-10 09:464 q9 b& p5 u4 \5 s
cell fusion create new species, gene mutation induce variation- n, V1 n. A! C% T& Z2 x: s' l" Y
2011-12-10 09:36
1 N+ J9 ^& k' T* W9 D' TGVT will be cancer terminator， Cytokine storm will be cancer preventor
+ u) A+ h$ M7 E) @# l  d  _2011-12-8 12:56
4 u3 W% L' |7 hcell fusion results regeneration，reprogramming，neogenesis，atavism； cell division results differentiation，apoptosis，senescense，development;  V8 C1 P2 [; [7 {& Y# ^
2011-11-27 14:54
7 w% [! ~9 ]  c5 JCancer is between protozoa and mesozoa， not metazoa...& e/ @; h, X: a" e; |  l% _
2011-11-27 00:25
# _$ j2 w4 k, E& G- Gcancer is neurological disease！ haha，I got it！1 {9 I; Y- D$ d
2011-11-22 22:06% v* c. Q3 o5 `& i5 B* _3 G
you are cancer，fetus is tumor. 佛曰：汝既是癌 癌胚如来
* I5 y' P4 p' X9 ]2011-11-12 11:27. z& H! Y* N7 t* n5 m
cancer is the ecological invasion of hacker...3 O; V2 U% d" b! H
2011-10-5 10:313 i! o% a9 T  @& ]1 \6 ?
microRNA is  negentropy？
: e& _) l* K! O/ E" w7 q- x2011-9-24 00:48& B& }% \5 f6 ~7 r( j/ m3 j
cancer is the social problem
) I# f. B; K6 k$ S0 Q5 f; |1 p5 }2011-9-9 23:33
6 C/ m. Y) y& t: g% @Science is the games of nobleman or madman
- X1 Q) f8 U; B+ r4 B: @8 e- a2011-9-2 15:03
, s# v  \$ I7 N# F- Kcancer resulted from disturbance of biological liquid crystalline state of ECM
) _) }1 @- s: a1 r- s2011-9-1 20:13
" S( D7 Z: |5 o& @4 V: o' aniche n-dimensions——space, time, momentum and entropy; energy, material and information flows; physical, chemical and biological factors；topological, thermal, and fractal influences.... P% |) ?/ j( s# u' z* D
2011-8-13 00:371 b6 c) b, K% f
Second recession is coming？
% Y' Y5 V+ d2 f5 c4 m2011-8-9 23:58) S" p5 ]. P7 g# U6 X
cancer may be from sexual reproduction of somatic cells.
1 A! i9 l; Z( V2011-8-7 00:16
4 q. f) W8 Q6 {3 a" G' owho determine gene？ genetic determinism is fatalism！
+ u1 q8 I9 N0 `+ k2011-7-30 11:26  Y% I- S" ?: Q  {! }/ f
niche reprogrammabllity is the key of solving cancer problems...: |& T2 p# A2 \: J# `7 V3 M
songtianlong: i can't agree more!!!O(∩_∩)O~ (8-14 20:42)
* g" w' |: {' ~sunsong7: hehe. thanks for interested in this topic, welcome future discussing (8-14 20:54)
: x" m: w. K, k% d, A" T% m% f' V2011-7-24 01:24& U$ D: I  x4 s: }
cancer results from acquired genetics alterations.
# \( {+ G2 d- w' r' {2011-7-20 21:37
7 q9 T& b& Y9 T6 n* G; cCSCs are the low differentiated cancer cells in G0/ H2 K; Q  x7 m# S/ R- S
2011-6-29 16:30
3 K3 k$ K& L* P' LiPS future——in vivo direct reprogramming ...
2 P& I/ o5 ~+ }/ ]! q; r3 v2 V; |2011-5-31 15:20% L4 {% F; m, f1 b1 P5 T, a
niche reprogramming——cell fate will be manipulated by cytoplasm - microenvironment interaction http://www.stemcell8.cn/thread-40755-1-1.html) r( i4 ~6 O( B5 f  k! [+ a7 ?
2011-5-31 01:28& z* o5 @+ l4 b! A0 R5 J
all the somatic cells of Mammals are totipotent ！
' \  b4 J$ b2 z: S2011-5-22 22:22
0 [2 z1 U; h! [! ]miRNA——The manipulator of  cell fate！
! B9 B# o; u, B( Z7 k0 ^0 q- y2011-5-20 20:21& `7 |" M! ~9 j
《Cell Stem Cell》means “cell is stem cell”   活细胞就是干细胞？) E* ?% h7 O8 I9 T* g8 N, i$ j( I0 I$ O
2011-5-17 12:38& x, p. M; D" v0 }
cancer —— good nuclear in bad cytoplasm！RNAs are cytoplasmic determinants determine  cytoplasm determine cell fate！ division is differentiation is cancerous is life ！  W1 D' J+ h, H; D7 [/ R/ A! Y
2011-5-11 12:31
. `) l* _3 G3 W" o# vcancer results from cell dedifferentiation...
& ~9 n4 X! L7 I! U4 Y8 J& B- }2011-4-28 18:073 |3 ^- z: O3 h  X. Y" k4 z+ s# {
differentiation——asymmetric cell division ！$ n4 \2 O+ U. A- \  K7 L
2011-4-28 18:04% I7 X3 K' Y; W' J) D; V: t
cancer origins from the regenerative cells！4 J2 c* E. r( [6 ?
2011-4-28 17:52
( i" d& ]7 d$ U4 _+ tProliferation is differentiation potentiality！) {; g6 g. R* ?" C
2011-4-28 17:49
+ W/ V" {: ^& B+ \( aiPS——the key of Pandora box！- X; _! G. h0 ?6 A
2011-4-27 22:36/ ]3 ]& j7 X' w1 d9 ]
Aristotle— "The whole is greater than the sum of its parts."3 r& V3 b6 e1 Z' X0 q3 [! m& _
2011-4-27 00:202 E# V3 M4 u" F
cancer——atavistic cells% \! `1 l, \3 d+ O5 e
2011-4-20 00:20
8 p$ S& A" s* d" p  x% ~cancer——cellular atavism！
& |7 v7 L3 Z5 \9 j6 O, K; t3 W2011-4-20 00:187 A! e4 l$ T( S, D
cancer——evolutionary ancestors of mammals.
/ d2 H7 ~2 j2 ~5 E/ {2011-4-20 00:099 _6 S/ @7 c# k8 J
肿瘤是细胞自组织缺陷的产物 . A7 i5 Z7 H% T! `
2011-4-17 01:41
; J2 f% k( y5 R5 n1 O5 {/ wcancer——Metazoa 1.0
/ h2 D3 m2 h# B% H2011-4-17 01:00
5 f2 a# `* e3 ^US——the Axis of Evil！: V& w& j9 x% y1 S; l1 W  K3 O
2011-4-4 01:19
# i4 k2 X+ `% {. @+ F美国是世界的邪恶轴心！
( c. M7 [( K9 c- ]6 ^sunsong7: 沁园春.血               ---作者：萨达姆   日 本 风 光, 千 里 地 震, 万 里 海 啸。 望 仙 台 内 外, 废 墟 莽 莽； 东 京 上 下， 顿 时 逃 逃。 核 站 爆 炸， 世 界 惊 涛， 地 震 海 啸 试 比 高 ... (3-22 21:25)7 }$ ?, p( s" a6 E2 c- c1 T% q: b
2011-3-22 19:06
/ X8 x8 e: y1 A. o* D4 cteratoma is derived from endogenous iPS！0 E7 X9 ?; _" V0 l7 C
2011-3-15 21:44
+ o* {1 x5 w, t& E) N! Bips is a luxury gambol on  , j! F' C! y, o6 l, T. ]5 ~; L2 s& P# ^
2011-3-3 14:50
/ _% L9 r/ g$ kcancer is intermediate of species evolution
1 m; j- x# O3 a2 I- C) B' A2011-2-12 12:29
: V' O6 D1 ~0 r+ Fstem cell now is on the eve of coming medical revolution9 a1 K% G! a7 `$ m; H# v' r9 e, [
2011-2-12 11:20
1 B  b( z! c0 |# g2 gInflamation is the reprogramming process of somatic cell in vivo！6 d- k4 @, ], n7 h; |' R
2011-1-31 14:49
# j# M) ?; V2 }/ U) Q9 z7 M3 aso-called medicine is niche regulator！9 q1 E+ T* O) k, D) [( X5 Y: m
2011-1-23 21:45- `! z* ~& s: e8 v+ |
endogenous iPS is the cancer initiating cell！
! H4 i4 x: V/ B2011-1-17 16:47
# f# U1 B( z" f! F/ y1 hcancer is unicellular organisms！  v, F" ~; f' L+ S
2011-1-9 22:04; k8 o7 K6 ?: H/ o/ N& e+ F
Pandorabox Has Been Opened  @* l; o2 l  K8 ?* T0 Z% }/ a  [. P
2011-1-7 23:248 K1 R5 F. v, `5 i- ~- ^
iPS is the Emperor's New Suit ! 
! k# w! H0 Y' f  v  H2011-1-5 23:50. N. c1 _, s3 C: U" L
cell-free is the final solution of stem cell therapy: b/ R  S5 e- W3 G! |
2011-1-5 21:46
  p7 y6 @& y: s0 [* U) ?niche is telling the story of stem cell...
/ ]7 U7 w- g2 T$ e2 x2010-12-29 17:32. O/ H: b" Q7 J" p/ c9 |8 X1 N
cancer results from reprogramming of somatic cells
: G# L0 _6 R$ T2010-12-25 18:56! Y# \: [* x) f9 w+ D) u3 s
cancer——good cells in bad niche！1 a( E4 \7 m: S7 @8 [9 V
2010-12-25 16:02
9 K6 @2 q4 s; d, \  F/ rcancer无罪——制造产生罪犯的土壤才是真正的犯罪！! q+ l! B1 L8 B4 {8 z. _: m
deron: 灰常同意，有相关文献么？ (12-19 09:41)
  a, N% ?, a5 w( W: m1 h/ Csunsong7: 呵呵，请来参加讨论——癌细胞的发生可能是一种“返祖”现象？ http://www.stemcell8.cn/thread-32073-1-1.html (12-19 11:33)
5 V( k1 V$ X! b. x6 dsunsong7: 问题讨论 http://www.stemcell8.cn/forum-re ... 709-pid-246202.html (12-19 13:29)
  [5 Y8 m9 s7 s9 X+ N: }2010-12-18 15:54" H$ X0 v* l$ R0 ^8 E: E& G9 z
子曰：上善若水 大成若缺——干细胞治疗的终极解决方案将是不移植外源干细胞！+ b+ ?& t* T* m- |
2010-12-15 15:07
! _0 Y# Z6 @" ~7 D6 N老狼的记忆——大洪水
+ _# {( M) P6 A. z+ V( J2010-12-13 23:25* Z% L0 l+ v! _) S( S7 B
can cancer randomly differentiate into norml cell in vivo  
6 E- j. M: W% u# f1 F$ ?. N2010-12-13 22:33! x, h$ E% D3 ?) c+ L  j- |
omnis cellula e cellula
" R. @  x+ J2 b, H! u0 O1 n% J2010-12-12 09:28, [. k6 ?+ d4 x6 ]$ c
Stem Cell ——The Origin of Disease4 x3 R0 ^8 J3 N" M% ?9 b7 _
2010-12-12 09:275 W4 p' y3 n* R

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